Lauri, thanks so much.
I admit I’ve been avoiding the comments here for a while. So very many of them have the flavor of people walking up to a cancer survivor and going “CANCER ISN’T REAL, SHOW ME YOUR MEDICAL PAPERS OR GTFO.” Who does that? My God.
It’s not a criminal trial, it’s a job interview. I wouldn’t hire him.
The burden of proof for a criminal trial is “beyond a reasonable doubt” for a good reason. My rapist would probably never have been convicted. Probably neither would Brett Kavanaugh. Galling, but I’ll have to live with that.
This is a deeply uncharitable read of my essay, if indeed you read my essay. (Should have known better? What? Ah, if only I had a time machine to go back to my 5-year-old self and tell her…um…honestly, I’m not sure what. That if she tells somebody she’s being tortured, she’ll get rescued, I guess. But I already ticked that ticky box. Good job…
I recommend checking out the MILES paper, which so far is the deepest look at the biological mechanisms underlying metformin’s observed clinical effects. The scientists involved in this work are still working to understand exactly how metformin interacts with biological pathways involved in aging, and there is more research underway.
There’s still lots of trout in the Esopus. Sometimes my neighbor who fishes the Pepacton Reservoir catches more than he can eat, and drives by my house and hands me a nice big one in a plastic grocery bag.
Hope you get to land one sometime.
Here’s a link to the MILES study: https://www.researchgate.net/publication/322831245_Metformin_regulates_metabolic_and_nonmetabolic_pathways_in_skeletal_muscle_and_subcutaneous_adipose_tissues_of_older_adults