New findings made the growth of human corneal tissue much easier!

Limbal stem cells, which reside in the eye’s basal limbal limbus, play an important role for them help maintain and regenerate corneal tissue. However, the lost of them because of injury or disease accounts most of the causes of blindness.

Fortunately, recently, researchers had found a new way to enhance the regrowth of corneal tissue by using a molecule named ABCB5 to restore vision, which indeed is good news for those fighting against blackness. In the study, the researchers applied antibodies detecting ABCB5 to zero in on the stem cells in tissue from departed human donors, aiming to use them to regrow anatomically correct, fully functional human corneas in mice.

As is known to us all that limbal stem cells are very rare, and they are the key factors of successful transplant. The study had found that ABCB5 also exists in limal stem cells and has significance in its maintenance and survival, as well as in the corneal development and repair. The study had also shown that a mouse without ABCD5 had poor recovery when injured in the corneal.

This mouse model had brought ABCB5 to a new level and had given a novel aspect for the research of stem cell. Moreover, this research is said to be the first example of constructing a tissue from human-derived stem cell.

Creative Biomart, as the pioneer and undisputed global leader in recombinant antibodies, including ABCB5, makes it our responsibility to help those researchers to carry out their research smoothly and effectively and thus help more people out of blackness.

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