Perfect Minimalist NAPLEX Review.

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STATINS

Notable side effects include: Headache, fatigue, insomnia, dyspepsia, myalgia, increased LFTs, increased BG and A1C, and cognitive impairment. Monitoring parameters may include: Lipid panel, +/- LFTs, +/- CK. Note that co-administration with fibrates or niacin increases the risk of myalgia (muscle pain). A common counseling point mentions monitoring for unexplained…

Minimalist NAPLEX Review.

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1st Generation

Cephalexin Cefadroxil Cefazolin

Good activity against Gram + and modest activity vs Gram

  • Most Gram + Cocci (Strep & Staph)
  • Modest vs E.coli, K. pneumoniae, P. Mirabilis

2nd Generation

Cefotetan Cefoxitin Cefuroxime Cefuroxime Axetil

Somewhat increased Gram — activity

  • E.coli, Klebsiella, Proteus, H. influenza

Cefuroxime → Can enter CSF to treat meningitis

Cefoxitin and Cefotetan → good activity vs B…

Minimalist NAPLEX Review.

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Penicillins

Pen G → Admin: IV only

Pen V → Admin: IV or PO

Uncomplicated gram + cocci, mainly Streptococcus sp.

S. Viridians → Causes bacterial endocarditis (issue for IV drug users and people with prosthetic valves or murmurs. (Normal Flora of the Mouth)

S. pyogenes → Causes Strep Throat

Uncomplicated…

Minimalist NAPLEX Review.

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General Mechanism

Alkylation and cross-linking of DNA to prevent DNA replication and transcription

Cyclophosphamide

SOA

breast, acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), lung, lymphoma

SE

Myelosuppression, mucosal toxicity, neurotoxicity, alopecia, infertility, toxic in high doses, renal adjustments

Ifosfamide

SOA

lymphoma also testicular cancer, sarcomas

SE

Myelosuppression, mucosal toxicity, neurotoxicity, alopecia, infertility, toxic in high doses, renal…

Minimalist NAPELX Review.

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Request

Latent TB patient has expressed noncompliance with first line treatment due to daily intake and 9 month duration. What other recommendations can we provide to Infectious Disease Department about treatments to alleviate compliance issue?

Response

The first line treatment for latent TB is Isoniazid (plus pyridoxine) daily for 9 months. An…

Minimalist NAPLEX Review.

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Fluorouracil

MOA

Inhibits thymidylate synthase enzyme and inserted into base pairing to prevent DNA replication

SOA

colorectal, breast

SE

Myelosuppression, GI Toxicities, alopecia

Capecitabine

MOA

Prodrug of 5-FU, Inhibits thymidylate synthase enzyme and inserted into base pairing to prevent DNA replication

SOA

colorectal mostly (also breast, pancreatic)

SE

Myelosuppression, GI Toxicities, alopecia

Cytaraine

MOA

Competes with dCTP for DNA incorporation…

Minimalist NAPLEX Review.

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Hemostasis: Three main steps

1. Vascular spasm

2. Platelet plug formation

3. Coagulation (blood clotting)

Vascular Spasm

· Immediate vasoconstriction of damaged blood vessel

· Triggers

o Direct injury to vascular smooth muscle

o Chemicals released by endothelial cells and platelets

o Pain reflexes

· Most effective in smaller blood vessels

Platelet Plug Formation

· Positive feedback cycle (Increase itself)

·…

Minimalist / Pharmacist (Admin)

Primary Blogger for The Minimalist / Pharmacist

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