The only significant thing about human life is its utter insignificance. Fame is fickle.Wealth and power are not permanent.Death is inevitable.The human animal is no more important to Nature than the tiniest of microorganisms.
It is supreme irony that posterity remembers wickedness and evil more than it honors goodness and philanthropy. A few hundreds may remember Helen Keller, millions remember Hitler.
However, we can. create significance by playing our roles in a sincere manner, by trying to realize our potential, by trying to mitigate needless suffering in the world.