Preventing dementia by early risk-factors modification — An Abstract

Dementia is a very staggering health problem and referred to a number of conditions that cause loss of mental and cognitive abilities. The most common form of dementia is Alzheimer’s dementia (AD), which is dementia caused by Alzheimer’s disease. Alzheimer’s dementia is characterized by the death of neurons and the accumulation of amyloid beta (Aβ) and tau proteins in the brain. Demonstrating the incidence, preclinical and prodromal stages in order to find the feasibility of risk-factors modification and demonstrate the risk-factors that needs to be prevented is the utmost important to reduce the number of people suffering from dementia. This study was divided into two parts based on the two analysis that were done. The first one is incidence of clinical and pathological analysis and the second one is the analysis of risk factors. The prevalence based on clinical and pathological classification shows huge range of early stages in AD. The result shows that even as early as 40 to 44 years old, the individuals have entered early preclinical stage of dementia. It also shows that risk-factors prevention reduce dementia cases by significant numbers. The demonstration of the incidence, preclinical and prodromal stages of dementia that is caused by Alzheimer’s disease, promotes the finding of feasible risk-factors modification. This paper also shows a substantial impact of number of prevented dementia cases by risk-factors intervention.