COVID-19 disease which began its journey, in Dec. 2019, by infection caused by a new and unknown new nano sized severe acute respiratory syndrome coronavirus (SARS-CoV-2) from Wuhan city in China has assumed the dimension of very serious pandemic of the 21st century. In the last 6 months it has spread across the globe, infecting around 7 millions of people with a death toll of three hundred sixty thousands of people. In spite of best of efforts by researchers and experts working in worlds most advanced laboratories to develop COVID-19 specific drug could not yet get desired result which otherwise urgently needed to check the increasing morbidity and mortality.

Recent structural studies1on SARS-CoV-2 has revealed that the spike proteins of the virus first touch cells with a receptor-binding domain (RBD), docks onto angiotensin-converting enzyme 2 (ACE2) and initiates viral entry. From the point of view of a chemist docking should involve electrostatic interaction between two bodies bearing opposite charge. This is true, as recently positive charge has been observed on (SARS-CoV-2)2 and the ACE2 membrane is known to have negative charge3. The -ve charge on the cell membrane can be neutralized, to bring it at point of zero charge (PZC), by altering the acidic pH (<7) to alkaline pH (>7) in the surrounding cytosol fluids of the cell membrane; thus making ACE2 surface to be non-attractive to the virus. The simplest way to do so is to give water therapy to COVID-19 patient, while continuing with other treatment, at the initial stages by just allowing them to drink water of pH ~8 which can be prepared by adding commonly available baking soda powder in house-holds. The pH in the range of 5.5 to 8.5 is acceptable by W. H. O. for safe drinking water4. I, as a chemist, may, propose to treat COVID-19 patients by alkaline water and monitor the recovery rate by the treating hospitals. Surely, this very simple treatment may turn out a blessing for millions of people to save them from the suffering of scary COVID-19.


1. https://www.chemistryworld.com/news/structural-studies-offer-glimpse-of-how-coronavirus-initiates-human-cell-invasion/4011452.article)

2. X. Zhang, Q. Q, Q. Jing et,al., Electrical probing of COVID-19 spike protein receptor binding domain via a graphene field-effect transistor, arXiv:2003.12529v1 [physics.app-ph] May 27, 2020

3. M. Pekker, M.N. Shneider,The surface charge of a cell lipid membrane, J Phys Chem Biophys 5: 177 (2015)

4. https://www.who.int/water_sanitation_health/dwq/fulltext.pdf

Former Director, Scientist, DRDO, India, experience on several advanced materials including nanomaterials, authored 4 books on Nano Sci & Tech and many papers.