The biopharmaceutical industry’s prospects in 2022 and beyond continue to drive manufacturers toward more productive and versatile bioprocessing solutions. Rising demand, fierce competition, the advent of new modalities, and the digital economy all contribute to faster growth, posing new operational issues. These challenges include the demand for shorter timeframes and higher yields on a broad range of products. Increasing upstream efficiency is an excellent starting point for addressing some of these business drivers. One of the quickest and least disruptive ways to accomplish this is to strengthen the seed train, which helps overcome time and cost restrictions while also making upstream manufacturing nimbler.
“Remember that iconic rocking chair with wicker seat and the ski-like rocking base has long been a favourite because of its swaying action on the porch or “Veranda” relaxes you and boosts you up to be more productive”
Similarly, the concept of a rocking chair is implemented in the biological world, and a novel oscillating/wave/rocking bioreactor system is developed by Cytiva. The “WAVE” bioreactor is a newly developed technological platform for cell culture that initiates a wave of the medium by oscillating the platform and thus promotes nutrient exchange and oxygen transfer. In seed inoculum production and mammalian recombinant cell-based process development, wave-mixed bioreactors have increasingly replaced stainless steel stirred tank reactors.
Cytiva’s wave bioreactors provide a durable strategy for performing seed train intensification as part of a fusion fed-batch/perfusion process. Rocking motion or wave-induced motion bioreactors typically comprise a single-use bag containing cells and media and the bag is attached to a rocking platform. A gentle rocking motion provides the mixing and aeration required for the cells to grow efficiently and at high densities. Crucial process variables such as pH, dissolved oxygen (DO), and viable cell biomass can also be tracked and controlled.
The uniform wave movement offers a low mixing and venting technology that allows cultures to acquire larger densities without jeopardizing cell injury from submerged bubbles or foam build-up. As a result, rocking motion technology is appropriate for sensitive cell types without the addition of sophisticated media components or further adaptation efforts. One can reap the advantages of process optimization by using rocking motion bioreactors. Cytiva highlights the benefits of rocking motion technologies that can help industries meet critical business objectives and design a durable and versatile next-generation facility, in addition to its automation and single-use interoperability.
In conclusion, seed train improvement leveraging rocking motion technology increases flexibility and yields while decreasing footprint, prices, and timeframe. These elements work together to improve overall efficiency and agility, allowing a facility to adjust to the changing biopharmaceutical landscape.
Are you a healthcare professional looking to stay up-to-date on the latest developments in the field of biosimilars? If so, you don’t want to miss the upcoming biosimilars workshop event 2023 hosted by the Institute Of Chemical Technology Mumbai at the Novotel, Goa.
At the biosimilars workshop event, you will have the opportunity to learn from industry experts about the latest advances in the field of biosimilars. You will also have the chance to connect with other professionals and exchange ideas and experiences.
In addition to the valuable educational and networking opportunities, the Novotel Hotel is a comfortable and convenient location for the workshop. The hotel offers a range of amenities and services to make your stay enjoyable and productive.
Don’t miss out on this opportunity to learn and connect with industry experts at the biosimilars workshop event at the Novotel Hotel.
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Figure 1- Wave bioreactor comprising cells and media attached to a rocking platform (Image source-https://www.cytivalifesciences.com)
