Unlocking the Potential of Upstream Bioprocesses with Innovative Technologies
Author: Ashwin Naidu (Ph.D. Scholar, Institute of Chemical Technology-Mumbai)
In today’s world, biotechnology has become one of the most important industries, as it deals with the important area of human healthcare. It offers a wide range of opportunities to optimize the production of therapeutic proteins, vaccines, and other biopharmaceuticals. To achieve this, innovative technologies and processes in upstream bio-processing are essential. Upstream bioprocessing involves the use of bioreactors and mammalian cell cultures to produce therapeutic proteins.
Upstream bioprocessing has long been a critical aspect of the biotechnology industry, allowing for the efficient and cost-effective production of biologics such as vaccines, enzymes, and antibodies. In recent years, innovative technologies have emerged that hold great promise for unlocking the full potential of upstream bioprocessing.
One such technology is single-use bioreactors, which have gained popularity due to their ability to reduce costs and improve flexibility in bioprocessing. Single-use bioreactors are disposable, pre-sterilized vessels that can be used for culturing cells and producing biologics. They eliminate the need for cleaning and sterilization, which can be time-consuming and expensive.
Another technology that has gained traction in upstream bioprocessing is continuous manufacturing (Perfusion process). This approach involves the production of biologics in a continuous flow, rather than in batch cycles. Continuous manufacturing has the potential to increase productivity and reduce waste, as it allows for a more consistent and controlled production process.
Advanced analytics and automation are also playing a key role in unlocking the potential of upstream bioprocessing. By using sensors, data analytics, and machine learning, bioprocesses can be closely monitored and controlled in real-time. This allows for more precise and efficient control of factors such as pH, temperature, and dissolved oxygen, leading to improved product quality and yield.
As famous investor Warren Buffett once said, “The key to investing is not assessing how much an industry is going to affect society, or how it is going to grow, but rather determining the competitive advantage of any given company and, above all, the durability of that advantage.” The same principle applies to the biotechnology industry, and the adoption of innovative technologies in upstream bioprocessing is a clear example of how companies are striving to maintain a competitive advantage and drive growth in the industry.
In summary, the use of single-use bioreactors, continuous manufacturing, and advanced analytics and automation are enabling biotechnology companies to unlock the full potential of upstream bioprocessing. These technologies are helping to improve productivity, reduce costs, and enhance product quality, positioning the industry for continued growth and success.
Figure 1- Representation of a single-use bag (SUB) for bioreactor
(Image source-https://www.genengnews.com/magazine/288/markets-expand-for-single-use-bioreactors)
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At the biosimilars workshop event, you will have the opportunity to learn from industry experts about the latest developments in the field of biosimilars. You will also have the chance to network with other professionals and exchange ideas and experiences.
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