Oleksii GavrylenkoIntegrating AI and Real-Time Analysis in Synthetic ChemistryIn the rapidly evolving landscape of synthetic chemistry, the advent of automation and real-time reaction monitoring stands as a beacon of…Dec 16, 2023Dec 16, 2023
Oleksii GavrylenkoEfficiency and Unveiling Off-Target Mechanisms: A Comprehensive Review on Target-Based Drug…The search for innovative drugs is essential for improving lives in the ever-changing face of healthcare. However, a sobering reality lurks…Dec 2, 20231Dec 2, 20231
Oleksii GavrylenkoDe Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep-Learning Framework.Opioids are powerful drugs frequently administered to treat severe or ongoing pain. On the other hand, prolonged use of these medications…Nov 28, 2023Nov 28, 2023
Oleksii GavrylenkoAnalysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New…Medicinal chemistry, a field marked by continuous innovation and discovery, remains ever-evolving. Despite this continual change, several…Nov 19, 2023Nov 19, 2023
Oleksii GavrylenkoThe challenge of balancing model sensitivity and robustness in predicting yields: a benchmarking…The quest for accurate prediction of reaction yields is a key challenge in synthetic chemistry, with large-scale literature data often…Nov 9, 2023Nov 9, 2023
Oleksii GavrylenkoArtificial intelligence and machine learning in drug discovery and development. Article reviewOne of the outcomes of the Industrial Revolution was the replacement of hard human labor with machinery, although not completely. This did…Nov 5, 2023Nov 5, 2023
Oleksii GavrylenkoEnhancing preclinical drug discovery with artificial intelligence. Article reviewThe path from finding a possible pharmacological target to bringing a novel medication to market is a difficult and costly one in the world…Oct 28, 2023Oct 28, 2023
Oleksii GavrylenkoIntegrating Reaction Schemes, Reagent Databases, and Virtual Libraries into Fragment-Based Design…Lead optimization is one of the early Drug Discovery stages. This process aims to refine and enhance the properties of a lead compound…Oct 13, 2023Oct 13, 2023
Oleksii GavrylenkoBest practices in machine learning for chemistry. Article reviewChemistry has experienced a fundamental shift toward the use of statistical modeling and analysis in the constantly changing world of…Oct 8, 2023Oct 8, 2023
Oleksii GavrylenkoLigBuilder V3: A Multi-Target de novo Drug Design Approach. Article reviewDrug Development is always intricate, juggling tasks, expensive and time-consuming. Individuals striving to expedite this process devise…Sep 24, 2023Sep 24, 2023
