How Antacids Work?
Antacids drugs that neutralize acids in stomach, are given by mouth to relieve heartburn and indigestion. Drugs aimed at overcoming real or fancied over acidity are called gastric antacids. Their job is to neutralize excess hydrochloric acid and inactivate pepsin, two substances secreted by the stomach as a vital part of the digestive process.
Antacids are not completely harmless. The HCl production in the stomach is regulated by the stomach pH. If too much antacid is taken, the pH becomes too high; the result will be the so-called “acid rebound.” This means that ultimately more HCl will be produced than was present before taking the antacid. Some antacid products also contain the ingredient simethiocone to relieve gas.
Antacids work by neutralizing hydrochloric acid (HCl), the acid produced in the stomach to break down and kill bacteria and other germs. HCl is extremely caustic substance with similar composition called muriatic acid. It works locally in the stomach and do not need to be adsorbed to treat peptic ulcers. Antacids are distributed throughout the gastro intestinal track track and are eliminated primarily in the feces.
Most of the antacids combine three basic salts — aluminum, magnesium and calcium — with bicarbonate or hydroxide ion. Antacid which involve the neutralization of acid. They do this because the chemicals in antacids are bases which are the opposite of acids. When acids and bases are combined, they can neutralize each other. This neutralization alters the stomach pH level and makes the stomach contents less corrosive.