STUDIES of two experienced cancer researchers have been proven right after their research received so much controversy in the past.

The main contention of the study indicated that lower doses of Vitamin C incite cancer stem cell (CSC) growth. On the other hand, optimal doses of Vitamin C and Niacin, or Vitamin B3 destroy cancer stem cells. Very high doses promote CSC proliferation.

There was a study published in the journal Cell Biology International. It tested how high and low doses of Vitamin C and Niacin affect stem cell tumors of the intestines. The researchers discovered that when taking a concentrated dose of Vitamin C (and Vitamin B3) of 5–25 micromoles/liter (considered a low concentration), there will be an active process of reproduction of stem cell tumors in the intestines. At higher doses (100 to 1,000 micromoles), the stem cells are destroyed.

This peer-reviewed study is the leading one in a series of recent studies on the tested value of high-dose Vitamin C in controlling cancer stem cells (these are known to be the slower growing cancer cells). CSCs are basically immune to standard chemotherapy and radiation so they multiply slowly. If CSCs survive, the results are usually a rapid relapse of more aggressive cancer tumors for the patient.

This study and a host of others support Linus Pauling, a respected Nobel Prize-winning cancer researcher, who had this long-held view that Vitamin C can be used to prevent, control and even treat cancer.

Two studies from Professor Michael Lisanti of the University of Salford, UK discovered that Vitamin C and Antibiotics could be up to 100 times more potent at killing cancer cells than standard anti-cancer drugs. Professor Lisanti said that giving the antibiotic doxycycline followed by Vitamin C effectively deprives cancer cells of their fuel to regenerate, leading to death in the lab.

Just last August 2017, research groups from the UK and USA published their studies about Vitamin C injections helping to fight blood cancers. Researchers Benjamin Neel and Luisa Cimmino of the New York University School of Medicine and their other colleagues found that cancer growth, specifically leukemia, can be prevented by injecting Vitamin C into mice. They managed to promote the function of a specific gene through high Vitamin C doses.

Likewise, Children’s Medical Center Research Institute at UT Southwestern researchers found out that stem cells absorb “unusually high” levels of vitamin C. This enables them to regulate function and suppress the development of leukemia.

Lead author of the study Dr. Michalis Agathocleous said stem cells use Vitamin C to manipulate chemical modifications on DNA. Which means it can turn genes on and off.

“When stem cells don’t receive enough vitamin C, these [DNA-regulating mechanisms] can become damaged in a way that increases stem cell function but also increases the risk of leukemia,” said Dr. Agathocleous.

Conclusively, humans who take up higher doses of vitamin C than normal will regulate and stabilize CSC function. And suppress the chances of developing leukemia.

It was established that “Available studies indicate that vitamin C at doses of 4 g/kg b.w. (will generate) a pancreatic tumor mass reduction of more than 40% using a xenograft animal model,” said Physician Daniel Couturier.


Pauling promoted the use of Vitamin C for controlling cancer. On the other hand, his colleague Arthur Robinson suggested that Vitamin C at doses asserted by Pauling might actually increase the rate of tumor growth in experimental laboratory mice.

The latest research asserted that both men were right. While low doses promote cancers, high doses can kill cancers.