Next Generation Sequencing (NGS)
What is NGS ?
Next-generation sequencing (NGS), also known as high-throughput sequencing, is the catch-all term used to describe a number of different modern sequencing technologies including:
- Illumina (Solexa) sequencing
- Roche 454 sequencing
- Ion torrent: Proton / PGM sequencing
- SOLiD sequencing
These recent technologies allow us to sequence DNA and RNA much more quickly and cheaply than the previously used Sanger sequencing, and as such have revolutionized the study of genomics and molecular biology.
Here is an interesting video from TED-Ed on How to sequence the human genome.
Today NGS had generated a ton of sequence data, which are waiting to be explored. Bioinformatics data analysis can uncovered new finding from these data for better understanding of the biomedical BIG data.
- Lee CH, Chiu YC, Wang LB, Kuo YL, Chuang EY, Lai LC, Tsai MH. Common applications of next-generation sequencing technologies in genomic research. Transl Cancer Res 2013;2(1):33–45. doi: 10.3978/j.issn.2218–676X.2013.02.09