My thought on the one virtue that would make the biggest difference: Acceptance. This virtue, in my opinion, encompasses all virtues. To accept ourselves and others as we are, would mean Loving everyone. That is the one and only import of Vedanta. In order to be able to do this, we must be clear of what this life is about, our Goal and the pathway to get to the goal. Once we rid ourselves of the vices (impermanent), love that remains within us will shine forth (permanent). Then we will realize everything is as it is meant to be….Accept it!