The (Up)Rise of the Citizen Scientist

RebelBio
5 min readJan 23, 2017

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Go to the profile of Antonio Lamb
Antonio Lamb, COO of MicrosynbiotiX and author of this article.

“Knowledge belongs to humanity, and is the torch which illuminates the world.”

-Louis Pasteur

That wisdom came from one of the founding fathers of microbiology who made his revolutionary discoveries on vaccination and disease prevention more than 120 years ago. His words have never been more relevant than today. Our revolution is fueled by synthetic biology’s version of Moore’s Law in DNA synthesis and sequencing costs, and the emergence of community labs and biotech accelerator programs all around the world that empower citizen science.

Source: http://www.synthesis.cc/synthesis/2016/03/on_dna_and_transistors

When the human genome was finally sequenced on the 14th of April, 2003, it cost the Human Genome Project and its collaborators a whopping 2.7 billion USD. Today, those costs have disintegrated. Companies like Oxford Nanopore Technologies have even developed portable, USB-powered DNA sequencers, although they still have some kinks to overcome, they are the first generation products. Like the early computers of the 70’s and 80’s, there will be better and cheaper versions over time.

Source: http://www.labcritics.com/minions-first-complete-genome-sequenced-using-new-bioinformatics-tools-4070/

At the same time, the company is developing a DNA sequencer which plugs into your iPhone! When the costs finally scale and consumer versions are released, this could quite literally change the way we do scientific research forever.

The prototype Oxford Nanopore’s SmidgION, the world’s first DNA sequencer for iPhone. Source: http://www.frontlinegenomics.com/news/5452/just-a-smidgion-oxford-nanopore-announce-iphone-powered-sequencing/

Technological advances drove down the costs of doing scientific research to the point where anyone could build a molecular biology lab with only 500 dollars, an eBay account, and some human ingenuity.

A cost estimate in USD for setting up a basic DIY molecular biology lab. Source: http://www.mlo-online.com/the-quest-for-the-500-home-molecular-biology-laboratory.php
Source: Figure 1: DIY laboratory. Adapted from Nature article by H. Ledford [Source]
the-odin.com offers citizen scientists affordable reagents and consumables at fairer prices than the big companies.

As for more sophisticated projects where more equipment or additional collaboration is needed, biohacker/incubator spaces like BioCurious, Berkeley BioLabs, and CounterCulture Labs exist to fill that niche. In fact, the abundance of high-tech, state-of-the-art facilities are one of the reasons California is such an attractive hub for biotech startups. Of course, it would be ridiculous (and wildly incorrect) to think that California is the only place where such ecosystems exist. In fact, there are many dozens of biohacker spaces springing up all over the world, with new ones popping up every year.

The interior of a biohacker incubator space (BioCurious Labs), located in Sunnyvale, California
The interior of BioCurious Labs
The Central Dogma of BioCurious

For a nominal monthly fee of 50 USD for students or 100 USD for non-students to help offset the operational expenses, a citizen scientist can have access to virtually every piece of modern biotechnology equipment needed to perform basic genetic engineering, along with a supportive community of entrepreneurs, academic scientists, teachers, and activists to help guide him or her.

Last but not least, new avenues of funding have empowered citizen scientists in ways which we have never seen before. Websites like experiment.com make funding for scientific research more equitable, as projects tend to be funded based on the legitimacy and potential of the ideas proposed rather than solely on credentials.

Websites like experiment.com allow society to greatly expand the number of small scientific projects which get funded

Many projects which have been financed through experiment.com crowdfunding have eventually gone on to produce publications in scientific journals. Sometimes these projects even become profitable business ventures. Accelerator programs like IndieBio in San Francisco, and RebelBio inLondon, exist to help transform such projects into sustainable and profitable businesses that go on to raise Seed and Series A financing.

Two of the most diverse biotechnology accelerators in the world, run by SOSV
SOSV, a seed-stage venture capital firm which invests in a variety of early-stage companies

I also want to take this opportunity to to share my own thoughts on RebelBio’s call for applications. The invitation to join Rebellious Biotechnology goes far beyond just enticing you with dangling contracts of gold. Your hands, minds, and hearts are the inventive instruments of society-altering change for the advancement of mankind, and RebelBio is your ammunition. We as a community are passing the torch of human progress on to you, my fellow scientists, revolutionaries, and entrepreneurs. Though RebelBio respects the dedication and perseverance of a doctorate degree, admission to the program is a meritocracy. Unlike other accelerators, RebelBio scrutinises your propositions on the merits of your ideas, not just on your credentials. It is a program made for the true DIY garage scientist who is not afraid to roll up his or her sleeves and get dirty. For the incoming teams, I sincerely wish every applicant the best of luck in joining the uprising, and I look forward to seeing the revolutionary ideas of the next cohort.

It is truly an exciting time to be alive as biology is transitioning from a research discipline to an engineering one. We are witnessing the democratization of scientific inquiry and all the economic and social prosperity that it will bring us. Mankind has now scored a huge victory. The common and critically thinking man has claimed control of the true means of production: life itself.

source: The Scientist http://www.the-scientist.com/?articles.view/articleNo/34443/title/DIYbio--Low-Risk--High-Potential/

Antonio Lamb is COO of MicrosynbiotiX, a 2016 RebelBio company focusing on the development of novel microalgae derived aquaculture vaccines. Check our his Medium account here!

Applications are also open for the RebelBio accelerator’s next cohort in 2019 if companies or prospective entrepreneurs would like to take advantage of funding, mentorship & support for early-stage life sciences. We are based in London’s Imperial College White City Incubator. The accelerator aids outstanding new investible bioscience opportunities from around the globe. Making the impossible inevitable.

Find out more about us and other start ups at RebelBio with 3months of business, scientific and technical mentorship to make the impossible…inevitable.

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RebelBio

RebelBio is a pre-seed VC brand of SOSV that accelerated 78 biotech startups. It has since merged with SOSV’s IndieBio brand & is now based in NYC.