Professor Jørgen Jahnsen and PhD student Kristian Espeland of Akershus University Hospital and University of Oslo are responsible for a new clinical trial which aims to improve symptoms and control the inflammation of Crohn’s disease using Gliolan medication in combination with blue-light photopheresis. This approach will selectively cause the death of pro-inflammatory cells which contribute to the inflammatory bowel disease, whilst showing minimal short- and long-term side effects.
Inflammatory bowel disease (IBD) occurs in two main forms: Crohn’s disease (CD) and ulcerative colitis. Both types of inflammatory bowel disease are chronic, immune-mediated diseases affecting the gastrointestinal tract, particularly the bowel.
The exact cause of Crohn’s disease is unknown, but there are several factors hypothesised to be involved, including genes, autoimmune responses to the body’s tissues, previous gastrointestinal infections or an imbalance in the gut bacteria. The underlying pathology of Crohn’s disease is a T-cell-mediated response (T-cells are important for the activation of immune cells), characterised by an overproduction of pro-inflammatory components, i.e. activated hyperproliferative T-cells. …
The use of psychedelics as a tool to aid psychotherapy is controversial, even in 2020. But some psychiatrists think psychedelics could be used effectively and safely to enhance the treatment of patients with a range of mental health issues. Consultant psychiatrist Ben Sessa is one such doctor, and he has been conducting research and gathering evidence in this area since the early 2000s.
The Interdisciplinary Conference on Psychedelic Research aims to bridge the gap between the many academic disciplines that have important contributions to make within the field of psychedelic studies. …
In Somaliland, a northern area of Somalia that operates as an independent country, many of the population rely on frankincense for income. Frankincense is a resin derived from the Boswellia tree. However, the trees are being overharvested, and locals have found themselves in a poverty trap. Despite a huge increase in the price of frankincense on the global market, harvesters see little financial benefit. …
The Medical Research Foundation (the Medical Research Council’s charitable foundation) believes that investing in long-term research projects — research that will not just be valuable now but also beneficial later — is the key to effective medical advancement. The Foundation steps in to fund the most promising health research that will make the biggest difference, filling gaps left by institutions and the government.
Established as part of the Medical Research Council of the UK in 1926, the Medical Research Foundation has been providing funding to advance medical research in areas that receive little or no support for over 90 years. …
In the plant kingdom, disease is an exception rather than a rule. That is because plants have an immune system. A plants’ immune system consists of several signalling pathways that act together to counteract microbial pathogens. However, there is not enough known about the subcellular pathways that allow proteins to move within and out of the plant cell and ward off bacterial plant pathogens. Dr Clemencia Rojas, Assistant Professor in the Department of Entomology and Plant Pathology at the University of Arkansas, investigates how various plant proteins function in different subcellular compartments, to defend against bacteria.
In nature, plants coexist with other organisms, including microbes. Plant-microbe interactions can sometimes be mutually beneficial, but at other times be damaging, leading to plant disease. However, disease is generally an exception rather than a rule, because plants have an innate immune system that allows them to defend against potential disease-causing microbes. Plant immunity is complex and hundreds of proteins participate in this process. Plant immune proteins interact in multiple configurations and also interact with proteins produced by pathogens. Understanding how specific immune proteins interact and move within and out of the plant cell to combat pathogenic bacteria, is the focus of research efforts by Dr Clemencia Rojas and her collaborators. …
The work of Dr Jennifer Geddes-McAlister at the University of Guelph investigates the interactions between hosts and pathogens to uncover new treatment options to combat infections. Her lab uses a range of techniques centered around proteomics, the study of proteins, to progress knowledge of fungal and bacterial infections in humans and agricultural crops. The results of this research can be applied to novel treatment approaches to improve human health, and have economic implications for the cereal crop industry.
The recent rise in antimicrobial resistance presents a major threat to human health. Since the early decades of the twentieth century, antimicrobial drugs — particularly antibiotics — have been an effective first line of defence against many infections, from the trivial to the life-threatening. Unfortunately, pathogens are catching up. …
Professor Alexander Steinkasserer is based at the Department of Immune Modulation, University Hospital, Erlangen. His research interests are focused on the immune system, with the long-term aim to develop new therapeutic strategies for patients suffering from autoimmune disorders or in need of transplantation. Along with his colleagues at the department of Immune Modulation, Professor Steinkasserer has shed much light on the involvement of a protein, CD83, in regulating immune responses.
Immune responses are constantly being monitored by the body; an excessive immune response can lead to accidental damage of the body’s own tissues but a response that is too weak will fail to fight off the threat composed by pathogens like bacteria/viruses or cancer cells. …
Dr Aisling Caffrey is an Associate Professor of Health Outcomes at the College of Pharmacy, University of Rhode Island. For over a decade, Dr Caffrey has been studying the treatment of diseases in real-world clinical practice, an area Dr Caffrey has termed ‘treatment epidemiology’. Dr Caffrey’s expertise is in comparative effectiveness and safety research, where she studies the benefits and harms of healthcare interventions, including medications administered in hospital or long-term care settings, and prescriptions dispensed in outpatient settings.
Epidemiology can be defined as ‘the study of what comes upon the people’ (from the Greek epi-demos-logos) and is best known as the science underpinning public health. Historically, epidemiology has focused on the surveillance of disease, also referred to as ‘disease epidemiology’, studying what level of disease occurs and in which populations. Disease epidemiology identifies changes in disease over time, as well as risk factors for disease occurrence, and disease prevention efforts. As science and medicine have evolved, a natural extension of disease epidemiology is the study of how diseases are treated, a subject area which Dr Aisling Caffrey, University of Rhode Island, has coined ‘treatment epidemiology’. This field of study has a number of different names, including pharmacoepidemiology, health services research, real-world evidence, outcomes research, health outcomes research, or pharmaceutical/device health outcomes research. Most simply, this field studies the effects of healthcare interventions to treat disease, and all these other terms fall under the umbrella of ‘treatment epidemiology’. …
Encryption systems that are capable of surviving quantum computer attacks are urgently required, but the cybersecurity talent gap militates against securing cyberinfrastructure. Dr Aydin Aysu, Assistant Professor at North Carolina State University, is advancing the research and teaching of post-quantum secure encryption. He has developed a quantum-secure encryption system together with a new graduate program on hardware security and is currently developing design automation for lattice-based post-quantum cryptosystems
The future of cybersecurity relies on developing quantum-secure algorithms, implementing them on trusted hardware, and training cybersecurity professionals at scale. Indeed, the emergence of quantum computers places existing security standards under severe threat. New encryption systems that can survive quantum computer attacks are urgently required. At the same time, hardware attacks are a growing concern among cybersecurity exploits, particularly as reliable computing hardware is essential to all information security practices. Cryptographic operations executing in a hardware root-of-trust underpins the security guarantees in a system. If this hardware root gets compromised, the security enforcement mechanisms will fail. Finally, the supply of cybersecurity specialists capable of developing such post-quantum secure encryption system is lagging far behind the demand for expertise, creating the cybersecurity talent gap. It is anticipated that there will be 3.5 …
Immunotherapy is a type of cancer treatment that harnesses the immune system to destroy cancerous cells. Dr Li Zhang and colleagues at Toronto General Hospital Research Institute and the University of Toronto, are pioneering a new type of “off-the-shelf” treatment using a type of immune cell — a double negative T (DNT) cell. Dr Zhang‘s work shows that DNT cells are a safe and effective therapy to tackle many different types of cancer. Importantly, these cells can be produced in large numbers from healthy donors without gene-editing and successfully stored for future use.
While a diagnosis of cancer can be devastating, the good news is that there are more, and better, treatments available than ever before. Chemotherapy and radiation are perhaps the most well-known ways to tackle late stage cancer, but another type of treatment is also showing great promise: immunotherapy. Immunotherapy is already an established treatment route for several types of cancer, including certain types of haematologic and solid tumours and is also being trialled in many other forms of the disease. …
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