The shallowest and dumbest article I have recently read was by some computer science professor about why he thinks “all crypto should burn in hell.” I won’t bother linking to it, he didn’t say anything new. But this morning I was wondering about why that article pissed me off. …

In early 2021 our venture builder, Curiosity, co-founded Multiomic, a company that has a credible strategy to improve much of how we treat heart disease (or rather an even broader set of conditions called metabolic syndrome). And this will have a huge impact on our understanding of extending life. I…

I am a cliché tech entrepreneur. I spend my days hanging out in California, pitching VCs, hiring engineers, reading HackerNews/AstralCodexTen and searching for product-market fit. …

In recent days I heard a very similar story from many of my friends around the world: “the COVID crisis showed me that my friends, family, health and emotional well-being are much more important than I thought. And governments, mass media, money, corporations, social media posts are less important. …

Last night I didn’t sleep well. Decided to do a 48-hour fast and went to bed hungry, cortisol was up. So this morning I managed only 3–4 hours of focus before boredom set in. When I’m bored I either force myself to do something “useful” (e.g. gym) or do something…

Friends have been asking when I will write something again. There are two reasons I haven’t written much recently: I don’t have much else to say on the subject of biohacking and personal optimization. I have been focused on other things, and don’t yet have a sufficiently deep and coherent…

There are certain things, at certain times, that I start to acutely crave. These cravings are programmed behaviors that always execute in the same mechanical, linear way. I’d like this to not happen. So I spent a bunch of time closely observing how these programs execute. …

Other deep-dive articles by Serge: — I’m 32 and spent $200k on biohacking. Became calmer, thinner, extroverted, healthier & happier. This post is about how to use modern science and personalized medicine to make yourself healthier, more productive and…hackernoon.com How to biohack your intelligence — with everything from sex to modafinil to MDMA I had some free time over the holidays and wrote this article to showcase, on the basis of a personal story, many…hackernoon.com

NONFICTION BOOKS I FINISHED IN 2017: — Behave by Robert Sapolsky — neuroscience of human decisions and in-particular a lot about the interplay between amygdala and pre-frontal cortex. Life 3.0 by Max Tegmark — explores concepts like what “intelligence” “memory” and “consciousness” are at a laws-of-physics level, and convincingly argues that these can be recreated in many…