In early 2021 our venture builder, Curiosity, co-founded Multiomic, a company that has a credible strategy to improve much of how we treat heart disease (or rather an even broader set of conditions called metabolic syndrome). And this will have a huge impact on our understanding of extending life. I…

Modern medicine already has the potential to be so much more than it is. In particular it can be high performance medicine. This is most obvious in sports. Elite athletes already have medical teams that get them to perform better at the goal that matters — results in their sports…

All my life I dreamed about using biotech for life extension and true, significant human enhancement. Why? I’m curious about what happens next. What do we find in the vastness of space and the depths of our own consciousness? …

I am a cliché tech entrepreneur. I spend my days hanging out in California, pitching VCs, hiring engineers, reading HackerNews/AstralCodexTen and searching for product-market fit. …

In recent days I heard a very similar story from many of my friends around the world: “the COVID crisis showed me that my friends, family, health and emotional well-being are much more important than I thought. And governments, mass media, money, corporations, social media posts are less important. …

Last night I didn’t sleep well. Decided to do a 48-hour fast and went to bed hungry, cortisol was up. So this morning I managed only 3–4 hours of focus before boredom set in. When I’m bored I either force myself to do something “useful” (e.g. gym) or do something…

Friends have been asking when I will write something again. There are two reasons I haven’t written much recently: I don’t have much else to say on the subject of biohacking and personal optimization. I have been focused on other things, and don’t yet have a sufficiently deep and coherent…

There are certain things, at certain times, that I start to acutely crave. These cravings are programmed behaviors that always execute in the same mechanical, linear way. I’d like this to not happen. So I spent a bunch of time closely observing how these programs execute. And developing approaches that…

Other deep-dive articles by Serge: — I’m 32 and spent $200k on biohacking. Became calmer, thinner, extroverted, healthier & happier. This post is about how to use modern science and personalized medicine to make yourself healthier, more productive and…hackernoon.com How to biohack your intelligence — with everything from sex to modafinil to MDMA I had some free time over the holidays and wrote this article to showcase, on the basis of a personal story, many…hackernoon.com