Get bigger, without Steroids!?

First off, I’m not condoning the use of steroids, but I do care about the health of these users. So, what if I tell you there could be a possible alternative to steroids?

With the recent news of steroids being still abused, such as bodybuilder Rich Piana dying of steroid use, it seems PEDs or Performance enhancing drugs, can be a touchy subject to many people. It can be seen as cheating as well as dangerous to a person’s health. But what if there is a possible alternative to steroids with less side effects. SARMs, the acronym for its official name, “Selective Androgen Receptor Modulator” is a drug similar to anabolic steroids. SARMs was originally created to prevent muscle-wasting in the elderly and for post-surgical patients. They are also for patients suffering osteoporosis, anemia, and chronic fatigue. Some SARMs are showing to be effective in their case subjects with little to no side effects. They were mainstreamed in the early 90s, but can be dated as far as the1940s. 
How does it work?
SARMs are known as muscle builders, similar to anabolic steroids. They work in the way through the manipulation of hormones. Think of it this way: Cells can be mailboxes, where hormone receptors carry out the mail from the cell (mailbox). SARMs target a specific hormone, which are called androgens. Androgens affect the body by binding to cell androgen receptors. Androgen receptors are responsible for enabling greater expression of specific genes, which encourages muscle growth. SARMs in this case, only bind to muscle and bone cells. There are 5 SARMs, which are MK-2866, LDG-4033, RAD-104, and S4 and GW50516.

MK-2866 is typically prescribed for the treatment and prevention of muscle wasting. It also has proven to be quite beneficial in healing as well as preventing injuries in tendons, bone, and ligaments.

LGD-4033 is a stronger version of MK-2866. It binds to androgen receptor and it is tissue selective. This means that it helps retain muscle loss, which is common with those who suffer from cancer. It is also used with those who are suffering from age-related muscle deterioration as well. This SARM acts like the steroid drug Testosterone, increases the rate of muscular growth, without the side effects of male like properties such as facial hair and a deeper voice.

S4 works by generating selective activity and it has 30% of the total strength when compared to testosterone at the moment it attaches to an androgen receptors. It is very useful in fat loss. How? S4 is the least anabolic, yet most androgenic of the SARMS. When it attaches to the androgen receptors in your adipose tissue or fat, it triggers fat oxidation.

RAD-140 will drastically improve one’s endurance and recovery. It interacts with the androgenic receptors in the muscle tissues and bones, but not receptors in other parts of the body. In patients it will drastically reduce cell death after suffering a stroke.

GW50516 is not technically a SARM but is classified as one. It increases the expression of genes involved in the expenditure of energy. In test studies, rats treated with GW50516 were shown to have increased fatty acid metabolism, as well as an increase HDL (good cholesterol) and decrease LDL (bad cholesterol).There are some that are categorized as SARMs, but are not technically SARMs. These are grouped with SARMs because they are also research chemicals, but since they are not SARMs, I won’t get into them.

What are the benefits of SARMs as opposed to steroid use?
Steroids are very well known in the community as great muscle builders, with some harsh side effects such as hair loss, increased prostate size, testicle shrinkage just to name a few. However, SARMs are much more selective on your androgen receptors, unlike steroids. They don’t break down into unwanted molecules that cause side effects, like DHT and estrogen.
SARMs do have their side effects though, but not nearly harsh enough to be compared to steroids. One thing for sure is that it suppresses your natural testosterone production. However, SARMs also aren’t as anabolic as steroids, meaning that they don’t suppress natural testosterone as much. There is also a greater chance of recovery towards regaining back your natural testosterone production. SARMS can also be taken orally, decreasing the risk of disease spread from injections for steroids. In terms of cost, SARMs are by far the best option, of gaining a far amount of size. Research does show that they are not as powerful as steroids, in terms of building muscle, but they are far stronger than any natural supplement you can find in any health store. While steroids can cause nearly $1000 for a month supply, but SARMS can cost more than 80% cheaper than the price of steroids. What’s better than a cheaper alternative steroid with little to no side effects?

As of right now, SARMs are currently legal to purchase online and over the counter. They are being sold as a research chemical and are not meant for human consumption. What does “research chemical” mean? SARMs are an investigational new prescription drug. A company named GTx has been working on whether this might have a chance at becoming a prescription drug. SARMs are banned by WADA (the World Anti Doping Agency). SARMs are banned due to the fact that companies sell them as supplements for muscle building. Note that, these research chemicals are still in phases of trials, before being consumed by humans. The FDA also banned certain SARMs due to some bad test results. Some test trials can be cherry picked, causing it have a bad rep. Let’s look at one SARM for an example. GW50516 is a SARM that enhances endurance. Reports later stated that GW501516 caused cancer in lab rats. But as with most substances, the devil’s in the dose. Studies did find that GW501516 is carcinogenic, but in the trial, 2400 mg a day for 2 years straight was taken. That’s about 240x a normal dose. So of course, overdosing any type of drug, can kill or hurt you tremendously. More SARMs are still being tested today and are ongoing to more phase trials. Despite SARMs being known as an alternative steroid, they are helping patients much better than the typical steroid. Some updated reports on trials and studies has given a 50% decrease in stress among women as well as increased body weight, lean mass and physical function during preclinical models of DMD (Duchenne muscular dystrophy).

Ill repeat this one more time: I’m not condoning the use of steroids, yet along SARMs. What I’m pointing out is there are other alternatives in the near future that could replace steroids and that could help with patients too.

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