Ceylon Cinnamon for Weight Loss
Cinnamon weight loss.
Cinnamon is currently marketed as a remedy for obesity, glucose intolerance, diabetes mellitus, and dyslipidemia. Integrative medicine is a new concept that combines conventional treatment with evidence-based complementary therapies.
The aim of this review is to critically evaluate the experimental evidence available for cinnamon in improving glycemic targets in animal models and humans.
Insulin receptor autophosphorylation and dephosphorylation, glucose transporter 4 (GLUT-4 ) receptor synthesis and translocation, modulation of hepatic glucose metabolism through changes in Pyruvate kinase (PK) and Phosphoenol Pyruvate Carboxykinase (PEPCK), altering the expression of PPAR (γ) and inhibition of intestinal glucosidases are some of the mechanisms responsible for improving glycemic control with cinnamon therapy.
We reviewed 8 clinical trials that used Cinnamomum cassia in aqueous or powder form in doses ranging from 500 mg to 6 g per day for a duration lasting from 40 days to 4 months as well as 2 clinical trials that used cinnamon on treatment naïve patients with prediabetes. An improvement in glycemic control was seen in patients who received Cinnamon as the sole therapy for diabetes, those with pre-diabetes (IFG or IGT) and in those with high pre-treatment HbA1c. In animal models, cinnamon reduced fasting and postprandial plasma glucose and HbA1c.
Cinnamon has the potential to be a useful add-on therapy in the discipline of integrative medicine in managing type 2 diabetes. At present the evidence is inconclusive and long-term trials aiming to establish the efficacy and safety of cinnamon is needed. However, high coumarin content of Cinnamomum cassia is a concern, but Cinnamomum zeylanicum with its low coumarin content would be a safer alternative.
Originally published at www.skinnybean.co.