Rob Hanna
Rob Hanna
Aug 24, 2017 · 1 min read

Great article, doc. Thanks for sharing!

The fasting and cancer treatment research work of Valter Longo and Dominic D’Agostino are also particularly exciting in this domain.

Please share a couple thoughts, from your experience:

  1. Does gluconeogenesis continue throughout fasting at all durations?

I’ve experienced some minimal amount of blood glucose circulating in all my fasts (even having fasted on water alone for as long as 28 days) and in all durations I’ve consistently tested to have blood glucose on labs, although lower than normal, e.g. in the 40s MG/DL…

and so:

2. Even if there is some baseline level of circulating blood glucose always available, do we have to get circulating blood glucose below a specific threshold to starve out cancer cells — or is it enough to simply drop insulin levels below a certain point during a fast and then regain normal to superior insulin sensitivity, regardless the glucose supply available, after the fast?

I understand cancer cells cannot function well, or at all, on ketones and presume cultivating a highly ketoadapted metabolism based on free fatty acids, acetoacetate and beta-hydroxybutyrate is not an issue.

Would also be helpful to know if there are effective thresholds of ketoadaptation by ketogenic diets more preferable than others as therapeutic adjuncts. I suspect these thresholds are also dependent on presence or absence of hyperinsulinemia, not sure.

Thanks for any thoughts here!

)

    Rob Hanna

    Written by

    Rob Hanna

    I’m an Innovation Adoption Architect—meaning I help others improve social and environmental baselines with impacts at scale. Let’s all improve the world!