Ingredient: Sodium Fusidate
Manufacturer: Abdi Ibrahim
Brand Name: Fucidin
Category: Antibiotics
Fucidin 500 mg Sodium Fusidate
Item price: $2.40
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Fucidin should not be applied to the skin in the eye area, since fusidic acid, in contact with the eyes, causes irritation to the conjunctiva.
Fucidin cream contains butylhydroxyanisole, cetyl alcohol and potassium sorbate, which can cause local allergic skin reactions (for example, contact dermatitis). Butylhydroxyanisole can also cause irritation of the eyes and mucous membranes.
Fucidin ointment contains lanolin and cetyl alcohol, which can cause local allergic skin reactions (for example, contact dermatitis).
When using fusidic acid, bacterial resistance may develop. As with other antibiotics, prolonged or intermittent use may increase the risk of antibiotic resistance.
Influence on the ability to drive vehicles and work with mechanisms. No effect on the ability to drive vehicles and complex mechanisms has been identified.
Mechanism of action and pharmacodynamics
Fucidin is an antibiotic that has potent activity against staphylococci, including Staphylococcus aureus, Staphylococcus epidermidis, and methicillin-resistant strains. Fusidic acid belongs to the group of fusidines, antimicrobial compounds that act as inhibitors of protein synthesis in a bacterial cell. By blocking the elongation of factor G, they prevent its binding to ribosomes and guanosine triphosphate, which interrupts the release of energy necessary for protein synthesis and leads to the death of a bacterial cell.
At a concentration of 0.03–0.12 μg / ml inhibits almost all strains of Staphylococcus aureus. Staphylococcal strains resistant to penicillin or other antibiotics are sensitive to Fucidin. Cross resistance as well as cross sensitivity to Futsidin no. Fucidin is characterized by low toxicity and is used when other antibiotics are contraindicated, for example, in the presence of an allergy to penicillins and other antibiotics and in renal failure.
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Pharmacokinetics
After a single infusion at a dose of 500 mg for more than 2 hours, the maximum concentration of sodium fusidate in the blood (C max) is 52 μg / ml. With repeated infusions every 8 hours for 2–3 days, it accumulates and C max reaches 60–120 mcg / ml.
The elimination half-life is about 10–15 hours. Communication with proteins (albumin) more than 95%. Fusidic acid is equally well distributed in tissues with low and high blood supply. High bactericidal concentrations exceeding the minimum inhibitory concentration for staphylococci (0.03–0.16 μg / ml) are created in purulent discharge, sputum, soft tissues, heart tissues, synovial fluid, sequestra, scabs, bones, in brain abscesses and intraorbital abscesses. Fucidin is metabolized in the liver and excreted with bile through the intestines, only in small quantities through the kidneys. It crosses the placenta and in small amounts into breast milk.
Indications
Treatment of infections caused by staphylococci sensitive to Fucidin: osteomyelitis, septicemia, pneumonia, endocarditis, cystic fibrosis. infections of the skin and soft tissues, wound infection.
Contraindications
Hypersensitivity to any component of the drug.
With caution — in case of impaired liver function, obstruction of the biliary tract, impaired transport and metabolism of bilirubin, jaundice, during treatment with hepatotoxic drugs, when combined with lincomycin and rifampicin, in newborns with jaundice, acidosis, as well as in premature or newborns with other severe illnesses.
