What are these ‘synthetic marijuana’ drugs?

Cannabis users and scientists need to know

They are synthesized chemicals, made in a lab, that interact with CB1 receptors in our bodies, but otherwise have nothing in common with marijuana. Some of them are stolen ideas from pharmaceutical patents, inventions made and then discarded by a drug company. Some are just molecules made by chemists playing around in the lab that someone figures out how manufacture and ‘make a buck’ foisting them on people looking for a ‘higher high’.

These are the drugs creating ‘Zombielike’ state that you read about [*1]

For example, here is a simple ‘stick figure’ of AMB-FUBINACA:

These ‘stick figures’ are THC and CBD show there is no nitrogen and no fluoride atoms, and yet the CB1 receptor accepts THC and AMB-FUBINACA but not CBD:

Here is a remarkably honest report from a drug chemist describing his personal experience with one such synthetic drug:

“In the last week XXX and me have tested 5F-AMB by combustion on tobacco in a pipe and thermal vaporization in a crack pipe.

5F-AMB causes two toxicities — one never yet seen in synthetic cannabinoids.

The first is unique and it’s next-day lung damage due to even the tiniest amount of 5F-AMB inhaled — even by thermal vaporization. The symptom is unique: a dry cough that worsens with use.

The second toxicity can be found in other 5F cannabinoids such as 5F-AKB48: the body only slowly eliminates many of these molecules. However, compared to 5F-AKB48 whose Adamantyl group is easily hydroxylated (see detailed post below), 5F-AMB’s methylbutanoate group (the rest being identical between them) renders it nearly impossible to metabolize.

The result is that while even large consumption of 5F-AKB48 during previous night leaves a toxic smell on sweat the next day, it’s gone by evening. In the case of 5F-AMB, that toxic smell on sweat and breath remain with very little reduction into the next day’s night.

When the body cannot break down or easily excrete via kidneys a drug, then it passively diffuses out of skin pores and lungs. That awful smell which lingers on and on and on.

I can smell it on my hand even as I write this post and my last dose was no greater than a milligram or two close to 24 hours ago. It’s a unique smell and unmistakeable.

5F-AMB produces unique toxicities and they last many times longer than any other synthetic cannabinoids. Unlike the kidney damage associated with 5F-UR144 which only affected a tiny fraction of users with peculiar genetics who couldn’t handle the tetramethylcyclopropyl group whose unique presence in these two drugs is the unmistakeable cause, 5F-AMB contains no unique group but the entire drug structure is uniquely put together from common parts like the Fluoropentyl and Methylbutanoate.

Yet despite the common groups, the particular combination of them in 5F-AMB yields an unexpectedly toxic molecule with very high metabolic resistance not present in other cannabinoids that make use of either the common two groups of Fluoropentyl or Methylbutanoate.”

We can thank some remarkable public health and medical scientists for figuring out and publishing their medical sleuthing in the New England Journal of Medicine [NEJM *2] that can be found at https://assets.documentcloud.org/documents/3239107/Zombie-Outbreak-Caused-by-Synthetic-Cannabinoid.pdf