Acetaminophen , Action , Uses, Administration , Side effect


Pharmacotherapeutic: central analgesic.

Clinical: Non-narcotic analgesic, antipyretic.


Appears to inhibit prostaglandin synthesis in the CNS and, to a lesser extent, block pain impulse through peripheral action. Acts centrally on hypothalamic heat-regulating center, producing peripheral vasodialation ( heat loss, skin erythema, diaphoresis).

Therapeutic effect : Results in antipyresis. Produces analgesic effect.


Route: PO

Onset: less than 60 min

Peak: 1-3 hrs

Duration: 4-6 hrs

Rapidly, completely absorbed from GI tract; rectal absorption variable. Protein binding: 20%-50%. Widely distributed to most body tissues. Metabolized in liver; excreted in urine.

Half-life: 1-4 hrs ( increased in those with hepatic disease, elderly, neonates; decreased in children ).

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