The Future of Newborn Metabolic Screening: Exploring Emerging Trends and Research

Trivitron Trivitron
3 min readJan 17, 2024

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In recent years, the landscape of newborn metabolic screening has witnessed remarkable advancements, paving the way for more accurate and efficient early detection of potential disorders in infants. As we delve into the future, emerging trends and ongoing research promise to enhance the capabilities of newborn screening, providing a deeper understanding of an infant’s health from the very beginning.

Early Detection with Trivitron Healthcare: A Pioneer in Newborn Screening Solutions

Leading the charge in this transformative era is Trivitron Healthcare, a trailblazer in newborn screening solutions. Trivitron’s commitment to ensuring the well-being of every newborn is evident in their comprehensive range of screening instruments, reagent kits, and automated solutions designed for the early detection of inborn errors of metabolism and various disorders in newborns.

Key Features of Trivitron Healthcare’s Newborn Screening Solutions

Trivitron Healthcare’s newborn screening solutions are characterized by their speed, safety, and efficiency. The company’s offerings include modular and fully automated newborn screening instrumentation, manual and automated equipment, and a diverse array of reagent kits. The Diagnostic division, Labsystems Diagnostics OY, a global leader in newborn screening technology under the Trivitron umbrella, sets the industry benchmark for quality and performance standards.

Innovative Technologies Driving Newborn Screening

Trivitron’s newborn screening products utilize cutting-edge technologies such as fluorescence and photometric detections. Notably, Trivitron Healthcare introduced the world’s first fluorometric microplate-based assay for screening phenylalanine to diagnose phenylketonuria (PKU) in newborns. This breakthrough technology exemplifies the company’s commitment to pushing the boundaries of innovation in the field of neonatal screening.

Furthermore, Trivitron’s screening solutions leverage liquid chromatography-tandem mass spectrometry (LC-MS/MS), significantly expanding screening possibilities by monitoring levels of amino acids and acylcarnitines. These tests serve as valuable second-tier confirmation tests, differentiating between true and false positive samples and detecting multiple disorders with a single injection — a crucial aspect for high-throughput laboratories.

Diverse Range of Newborn Screening Assays

Trivitron Healthcare’s newborn screening assays from dried blood spots (DBS) include tests for thyroid stimulating hormone (TSH), 17-hydroxyprogesterone (17OHP), glucose-6-phosphate dehydrogenase (G6PD), galactose, and immunoreactive trypsinogen (IRT). These tests play a pivotal role in the early detection and screening of various disorders, enabling prompt diagnosis and treatment.

The Advantages of Trivitron’s Screening Technology

Trivitron’s newborn screening technology is founded on chemical enzyme assays and monoclonal antibody-based enzyme immunoassays utilizing a microtiter plate and photometry technology. This approach has demonstrated effectiveness in case finding and offers several advantages, including reduced labor, ease of handling, the use of nonradioactive reagents, a long reagent shelf-life, better specificity, and a reduction in potential sample handling and transposition errors.

In conclusion, Trivitron Healthcare’s newborn screening solutions represent a paradigm shift in the early detection and screening of various disorders in newborns. With a focus on advanced instruments, reagents, and automated systems, Trivitron is dedicated to meeting the highest quality and performance standards in the industry. As we look towards the future, it is clear that Trivitron Healthcare will continue to play a pivotal role in shaping the landscape of newborn metabolic screening, ensuring a healthier start for every child.

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