In fact, the best large tech companies are successful because even though they’ve finally found their business model, they desperately try to remain startup and like to put themselves in a state of permanent danger. Tech companies can keep their small startup DNA if they remain in a state of perpetual search for a future repeatable and scalable business model.
From Startup to Company, One Step at a Time
Nicolas Colin

Do agree: big companies lose their adaptability (the capacity of “perpetual search“) as they become more and more optimized for efficiency. They have to find the right position in this trade-off (Going publish a post about that).