For about a year, life might be a struggle. But beyond that, I think it will matter less and less.
You can get USB-C adapters (HDMI), thumb drives, cables (C->micro/mini/Lightning) and card readers and as you buy those things piece by piece on an as needed basis, you’re future proofing yourself, because times they are a changing. USB-A is on borrowed time now, and it won’t stick around forever, I don’t care how common it is.
As for the physical escape key, I’d recommend remapping it to one of the other modifier keys, or figure out a useful way to embrace the softkey, either way, it’ll take about 2 weeks to fully adjust and correct your muscle memory.