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Advances in biological science

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Structural bioinformatics

Over a year of AlphaFold 2 free to use and of the revolution it triggered in biology

Confident modeling of protein structures, prediction of their interactions with other biomolecules, and even protein design are now at everybody’s reach thanks to the revolution started by Deepmind.

10 min readNov 28, 2022

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Picture generated by the author from own drawings plus Dall-E-2 generations to depict some subcellular structures and highlight protein structures in magenta.

Introduction | Democratizing the use of AlphaFold 2 and new adaptations of it | What’s next | Protein language models | Pre-made databases of structural models built with these modern tools | Unexpected things that AlphaFold 2 seems to be able to do | Further reads on the topic and on broader structural biology

Introduction

It all started when a private company played for the first time ever in a contest for protein structure prediction, and won it. Twice in a row, and it then released its star program in an open form for all scientists (also students, actually everybody!) to use for free. Moreover, its users don’t even need a powerful computer, because the calculation happens right on a GPU in the cloud!

We are talking about Deepmind, the Artificial Intelligence (AI) research company of the Alphabet group, owner of the most…

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Advances in biological science
Advances in biological science

Published in Advances in biological science

AdBioS is a science communication platform that aims to explain ground-breaking science in the field of biology, medicine, biotechnology, neuroscience and genetics to literally everyone. Scientific understanding has too many barriers, let's break them down!

LucianoSphere (Luciano Abriata, PhD)
LucianoSphere (Luciano Abriata, PhD)

Written by LucianoSphere (Luciano Abriata, PhD)

https://www.lucianoabriata.com | Scientific writing, technology integrator, programming, biotech, bioinformatics.| Have a job for me? Contact me in ES FR EN IT

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