Spinal Cord Development
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Spinal Cord Development
The spinal cord is made from part of the neural tube during development. As the neural tube begins to develop, the notochord begins to secrete a factor known as Sonic hedgehog or SHH. As a result, the floor plate then also begins to secrete SHH, and this will induce the basal plate to develop motor neurons.
Spinal cord seen in a median section of a five week old embryo.
Spinal cord seen in a median section of a 3 month old embryo.
Meanwhile, the overlying ectoderm secretes bone morphogenetic protein (BMP). This induces the roof plate to begin to secrete BMP, which will induce the alar plate to develop sensory neurons. The alar plate and the basal plate are separated by the sulcus limitans.
Additionally, the floor plate also secretes netrins. The netrins act as chemoattractants todecussation of pain and temperature sensory neurons in the alar plate across the anterior white commissure, where they then ascend towards the thalamus.
Lastly, it is important to note that the past studies of Viktor Hamburger and Rita Levi-Montalcini in the chick embryo have been further proven by more recent studies which demonstrated that the elimination of neuronal cells by programmed cell death (PCD) is necessary for the correct assembly of the nervous system.
Overall, spontaneous embryonic activity has been shown to play a role in neuron and muscle development but is probably not involved in the initial formation of connections between spinal neurons.
Law, Medical, Anti-trust, Expert Witness, Lawsuits, Cottage Hospital, Medical Legal Terms Spine Orthopedic Center: Alan Moelleken MD Bio – Dr Alan Moelleken Resume – Back Pain – Carpal tunnel syndrome – Chronic pain – Neck Pain – Rotator cuff tear – Spine and Orthopedic Medical Staff – Sciatic – Spinal Cord Development – Spinal Cord Motor organization – Spinal Cord Segments – Spinal Cord Somatosensory Organization – Spinal Cord – Spinal Cord Injury – Spinal Cord Spinocerebellar Tracts – Spondylolisthesis Spine Cord -
