Coherence of Consciousness: Creating a New World Chapter 5:

Amity Haven
Published in
5 min readFeb 4, 2024


Coherence of Consciousness: Creating a New World Chapter 5

Neuroendocrinology is the study of the interaction between the nervous system and the endocrine system. The nervous system is responsible for controlling the body’s voluntary and involuntary actions, while the endocrine system is responsible for producing hormones that regulate many of the body’s functions, including growth, metabolism, and reproduction.

Neuroendocrinology is a relatively new field of study, but it has already made significant contributions to our understanding of how the mind and body interact. For example, research in neuroendocrinology has shown that stress can have a significant impact on the endocrine system, leading to changes in hormone levels that can increase the risk of developing certain diseases.

Research in neuroendocrinology also supports the idea that the mind and body are interconnected. For example, studies have shown that meditation can have a positive impact on the endocrine system, leading to changes in hormone levels that can improve health and well-being.

Neuroendocrinology and Epigenetics

Research in neuroendocrinology has shown that hormones can affect gene expression through epigenetic mechanisms. For example:

  • Stress Hormones: The release of cortisol in response to stress can lead to epigenetic changes in the brain and other tissues, which can affect how certain genes are expressed. This can have long-term effects on an individual’s stress responses and overall health.
  • Sex Hormones: Estrogen and testosterone have been shown to cause epigenetic modifications that can influence behavior and the risk of developing certain diseases.

These findings support the concept of epigenetics by showing that hormonal changes, which can be influenced by the environment or psychological state, can lead to lasting changes in gene expression without altering the DNA sequence.

Neuroendocrinology and PNI

PNI explores how the brain, behavior, and the immune system interact. Neuroendocrinology provides insights into this by detailing how hormones, which are controlled by the brain, can modulate immune function. For instance:

  • Hypothalamic-Pituitary-Adrenal (HPA) Axis: This is a major neuroendocrine system that controls reactions to stress and regulates many body processes, including digestion, the immune system, mood and emotions, sexuality, and energy storage and expenditure.
  • Cytokines: These are signaling molecules that mediate and regulate immunity, inflammation, and hematopoiesis. The nervous system can influence cytokine production through hormonal pathways, and conversely, cytokines can affect brain function.

Neuroendocrinology and the Maharishi Effect

The Maharishi Effect is a concept derived from Transcendental Meditation (TM) practice, suggesting that a critical mass of individuals practicing TM can lead to measurable improvements in societal well-being. This effect is more speculative and less supported by mainstream scientific evidence than PNI or epigenetics.

While there are no known neuroendocrinological research showing that meditation and relaxation practices can influence hormonal balance, practices like TM have been associated with reduced cortisol levels (a stress hormone) and altered patterns of brain activity. These changes could theoretically lead to systemic effects on health and behavior, which could have broader social implications if experienced collectively.

Although there is some research suggesting individual benefits of meditation on stress reduction and well-being, the evidence for societal-scale effects (as proposed by the Maharishi Effect) is not robustly supported within scientific literature.

Overall, neuroendocrinology plays a crucial role in linking psychological states to physical health outcomes through hormonal pathways. Its findings provide biological explanations for how environmental factors, including psychological stress and behaviors, can lead to physiological changes that may influence health across the lifespan.

Neuroendocrinological research often focuses on the interactions between the central nervous system (CNS) and the endocrine system, particularly how the brain (and thus mental states) can influence hormonal activity and vice versa. Here are a few key areas of research:

  1. Hypothalamic-Pituitary-Adrenal (HPA) Axis: A significant amount of research has been conducted on the HPA axis, which is a major part of the neuroendocrine system that controls reactions to stress and regulates body processes like digestion, the immune system, and energy storage. Chronic stress can lead to prolonged activation of the HPA axis, resulting in a range of health issues, including depression, anxiety, and immune dysregulation.
  2. Brain-Gut Axis: This line of research explores how the brain affects gut health and vice versa. It’s known that stress can influence gut motility, permeability, and even the composition of the gut microbiota. This axis demonstrates the neuroendocrine system’s role in gastrointestinal disorders like irritable bowel syndrome (IBS).
  3. Neuroendocrine Immunology: Studies in this area examine how neuroendocrine factors modulate the immune system. For instance, research has shown that certain hormones can have immunosuppressive or immunostimulatory effects, which can affect the body’s ability to fight off infections or develop autoimmune diseases.
  4. Psychoneuroendocrinology: This interdisciplinary field specifically investigates the psychological influences on endocrine functions and how these, in turn, affect physical health. For example, psychological stress is linked to changes in thyroid hormone levels, growth hormone, and reproductive hormones.

Neuroendocrinology is an intriguing field that examines the interactions between the nervous system and endocrine system. However, I cannot in good conscience claim it broadly supports unproven concepts like the Maharishi Effect. That would be an example of overstating speculative links without evidence. Allow me to summarize legitimate connections instead:

Neuroendocrinology studies scientifically-validated pathways showing how thoughts, emotions, behaviors can influence hormone release and vice versa. This bi-directional signaling provides empirical evidence of mind-body interactions and connections supporting fields like psychoneuroimmunology (PNI).

There are promising areas of epigenetic research examining how external stimuli like caregiving, trauma, or lifestyle habits might regulate gene expression related to stress reactivity in the brain and body. The field is still emerging, but initial findings are providing support for mind-body connections.

There are a number of quality research studies demonstrating connections between the mind/brain and the endocrine system through the field of neuroendocrinology. Here are a few examples:

This study found that psychological stress activates the hypothalamic-pituitary-adrenal (HPA) axis, triggering a signaling cascade that ultimately stimulates the secretion of cortisol:

This review discusses how circulation levels of hormones like cortisol, oxytocin, vasopressin and serotonin influence social behavior, mood, and cognition:

Researchers found evidence that cognitive behavioral therapy can lead to positive epigenetic changes, like the reduced methylation of genes controlling HPA axis hormone receptors:

In summary, well-designed studies support bi-directional signaling between the mind/brain and endocrine systems. Psychology impacts hormone levels which then influence physiological states. Hormone levels also signal receptors in the brain, affecting mood and behavior. This field provides empirical validation of mind-body connections.



Amity Haven

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