Eight Lessons from John Stuelpnagel (Illumina)

Axial
Axial
Published in
5 min readMar 6, 2022

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John Stuelpnagel co-founded Illumina in 1998 as its first CEO. Trained as a biochemist, Stuelpnagel started working on CW Group (Larry Bock’s firm) after getting his MBA at UCLA. While working as a VC, he identified a unique invention out of David Walt’s Lab at Tufts: combining microwell arrays with beads attached to different DNA sequences to enable single nucleotide polymorphisms (SNP) detection. Stuelpnagel was a driving force to build Illumina around what work became their BeadArray platform. This technology quickly became the standard for genome-wide association studies (GWAS), along with Affymetrix, and set the company up to dominate next-generation sequencing — part acquiring Solexa and part out-executing Roche and Thermo. Stuelpnagel is still a leader in the field as chairman of…

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