Understanding Sports Supplements: What Works and What Doesn’t

Dr. Hussam Hamoush
BeingWell
Published in
5 min readAug 12, 2024

In the world of athletics, sports supplements have become a hot topic. From protein powders to creatine, these performance-enhancing substances promise to give athletes an edge in their pursuit of peak athletic performance. But with so many options on the market, it can be tough to separate fact from fiction. What really works, and what’s just clever marketing? This article aims to cut through the noise and provide a clear picture of the sports supplement landscape.

We’ll dive into the science behind sports supplements, exploring how they affect the body and impact performance. We’ll take a closer look at some of the top performers in the supplement world, like protein, creatine, and caffeine, as well as those with less scientific backing. Along the way, we’ll touch on important aspects like safety, potential side effects, and how these supplements might interact with medications. By the end, you’ll have a better understanding of what might actually help your workouts and recovery, and what might just be emptying your wallet.

The Science Behind Sports Supplements

How Supplements Work

Sports supplements are designed to boost athletic performance in various ways. These products come in different forms, including powders, pills, drinks, and snack bars. They aim to build muscle, increase energy, improve endurance, or assist in weight loss. The effectiveness of these supplements depends on how they interact with the body’s physiological processes.

For instance, protein supplements can help increase muscle production and reduce post-workout soreness and fatigue during resistance training. Creatine supplements have been shown to increase lean muscle mass, strength, and overall exercise performance. Caffeine, when consumed before physical activity, may delay the depletion of carbohydrates used during exercise, thereby improving endurance.

Research on Effectiveness

Studies have shown that some sports supplements, particularly protein, creatine, and caffeine, have strong scientific backing. However, the effectiveness of many other supplements remains limited or inconclusive. For example, while multivitamins, branched-chain amino acids, omega-3 fatty acids, and green tea extract are often promoted for various performance benefits, the research supporting their effectiveness is still limited.

It’s important to note that the quality of many studies on sports supplements is limited by small sample sizes, short durations, and poor control of confounding variables. This makes it challenging to draw definitive conclusions about their efficacy.

Placebo Effect

Interestingly, the placebo effect plays a significant role in the world of sports supplements. Athletes who believe they’re taking a performance-enhancing supplement, even if it’s just a placebo, may experience improvements in their athletic performance. This phenomenon, known as the “placebo effect in sports,” has important implications for evaluating the effectiveness of sports supplements.

Research has shown that the placebo effect can account for a significant portion of the observed benefits of sports supplements. For example, in one study, athletes who falsely believed they had been administered anabolic steroids performed better than baseline or controls. This highlights the importance of well-designed, placebo-controlled studies to accurately assess the true effectiveness of sports supplements.

Top Performing Sports Supplements

Whey Protein

Whey protein, derived from milk during cheese production, has become a staple for athletes and fitness enthusiasts. It’s rich in essential amino acids and promotes muscle protein synthesis, crucial for muscle growth and recovery. Consuming whey protein 30 to 60 minutes before exercise can provide necessary amino acids to prevent muscle breakdown during training. Post-workout consumption within 30 minutes can accelerate muscle recovery and facilitate muscle growth.

Creatine Monohydrate

Creatine monohydrate is one of the most scientifically supported supplements on the market. It enhances energy production in cells by helping replenish ATP, the energy currency of cells. This leads to improved high-intensity exercise performance, with studies showing enhancements of 1–15% in various exercises. Creatine has been found to increase maximum squat and bench press strength, as well as explosive power in jumps.

Caffeine

Caffeine is a powerful performance enhancer, improving both physical and mental performance. It’s rapidly absorbed into the bloodstream, peaking after 30–120 minutes. Caffeine activates areas of the brain and nervous system to improve focus and energy while reducing tiredness. It can increase circulating epinephrine, potentially improving performance. For endurance athletes, caffeine can significantly enhance performance, with a recommended dose of 200–400 mg consumed 60 minutes before an event.

Beta-Alanine

Beta-alanine is a non-essential amino acid that aids in the production of carnosine, a compound that plays a role in muscle endurance during high-intensity exercise. It helps regulate acid buildup in muscles, a primary cause of fatigue. While it doesn’t increase muscle strength or aerobic endurance, beta-alanine appears to slightly increase the duration an athlete can perform high-intensity exercises before exhaustion. Food sources include meat, fish, and poultry, but supplementation is often necessary to achieve performance-enhancing levels.

Supplements with Limited Evidence

While some sports supplements have proven benefits, others lack substantial scientific backing. Let’s take a closer look at three popular supplements with limited evidence of effectiveness.

BCAAs

Branched-chain amino acids (BCAAs) have gained popularity among athletes, but their benefits remain unclear. BCAAs, consisting of leucine, isoleucine, and valine, are essential amino acids that play a role in muscle protein synthesis and recovery. Some studies suggest that BCAAs may reduce muscle soreness after exercise and improve mental focus during workouts. However, when it comes to athletic performance and body composition, the benefits appear to be negligible.

The inconsistent findings across studies may be due to varying supplementation protocols and the lack of consideration for total daily protein intake. While BCAAs might activate anabolic signals, their impact on performance is minimal. Athletes should interpret the potential benefits of isolated BCAA supplementation with caution, especially since these amino acids are already present in many protein-rich foods and supplements.

Glutamine

Glutamine, a conditionally essential amino acid, has been widely used in sports nutrition due to its potential role in immune function and recovery. It’s thought to delay fatigue through various mechanisms, such as influencing gluconeogenesis, stimulating glycogen synthesis, and buffering ammonia. However, the effects of glutamine supplementation on fatigue markers and physical performance remain inconclusive.

While some studies have shown that glutamine supplementation may improve certain fatigue markers, such as increased glycogen synthesis and reduced ammonia accumulation, it hasn’t translated into significant improvements in physical performance. Both the International Society of Sports Nutrition (ISSN) and the International Olympic Committee (IOC) have classified glutamine as a non-effective supplement with little to no evidence of efficacy.

Testosterone Boosters

Testosterone boosters are over-the-counter supplements that claim to increase testosterone levels and alleviate symptoms of low testosterone. These products often contain ingredients like fenugreek, zinc, maca, and ashwagandha. However, there’s insufficient evidence to support their effectiveness.

Studies on these ingredients have yielded mixed and inconclusive results. For instance, research on fenugreek’s effects on testosterone has been inconsistent, and there’s no evidence that maca can increase testosterone levels. While some studies suggest that ashwagandha may increase testosterone levels, more high-quality research is needed to confirm these findings.

It’s important to note that the FDA doesn’t regulate these supplements as strictly as pharmaceuticals. Therefore, their safety and efficacy aren’t thoroughly scrutinized. Healthcare professionals generally recommend FDA-approved treatments for low testosterone rather than over-the-counter boosters.

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Dr. Hussam Hamoush
BeingWell

Drug store owner and Podcast Host. Stonebriar Pharmacy in Frisco, TX. Part time writer, Full time Advocate.