Intake of microplastics by living tissues and cells

Anurag Yadav
Biobuds
Published in
4 min readDec 31, 2020

Plastic, plastic, everywhere, with no nook to spare

Microplastics — another menace to the living world

Presently, plastic pollution is one of the prime problems faced by the world. There’s plastic everywhere, from the large oceans to microscopic living cells. Yes, you read it right, microplastics have found a way to inhabit the living cells without being excreted.

MICROPLASTICS

Microplastics aren’t a selected type of plastic, but rather any sort of plastic fragment that’s but 5 mm long consistent with the U.S. National Oceanic and Atmospheric Administration (NOAA) and the European Chemicals Agency. Primary microplastics are small pieces of plastic that are purposefully manufactured. Secondary plastics are small pieces of plastic derived from the breakdown of larger plastic debris. They enter natural ecosystems from a spread of sources, including cosmetics, clothing, and industrial processes. In 2014, it had been estimated that there are between 15 and 51 trillion individual pieces of microplastic inside the world’s oceans, which was estimated to weigh between 93,000 and 236,000 metric tons.

Image showcasing the distribution of sources of microplastics in the world’s oceans.

INTAKE BY THE LIVINGS CELLS

With the intention to prove the intake of the entry of the microplastic particles into an active cell, some microplastic particles were placed in fresh water from an artificial pond, while others were placed in salt water from a marine aquarium. Biomolecules (carbohydrates, amino acids, nucleic acids, and proteins) were deposited on the surfaces of these particles within two weeks exposure time. This formation of ‘Eco-corona’ around the microplastic particle makes it easier to internalize. In order to differentiate whether the particles are literally internalized or only adhere to the outside of the cells, important components of the cell interior, the actin filaments, were stained. On the resulting microscopic images, the internalized particles might be recognised as “dark holes”. This proved that the particles found inside the cell were microplastic.

Figure showing the formation of eco-corona on the microplastic. The greenish dots represent biomolecules which adhere around a plastic particle (orange in colour). This eco-corona formation establishes a mechanism for cells to internalise these microplastics

PLASTIC INSIDE HUMANS

With plastic causing pollution everywhere, it has become obvious that it will be found in our bodies. It has been long known that folks consume such minuscule particles through food, water, and even breathing. Researchers at the Arizona State University, carried out an experiment and looked at the samples from humans exposed to plastic significantly and found microplastics in every human tissue they studied. They studied 47 samples that were from tissues from different organs like lungs, liver, spleen and kidney. The most common chemical found was “Bisphenol A”, used in food manufacturing.

CONSEQUENCES

Plastics incorporated in the living tissues and cells can cause harm to a body in multiple ways. The harmful form of plastic contains bisphenol A, lead, mercury, dioxins, phthalates, and cadmium that can cause early onset of puberty, damaged neurological functions, compromised immunity, affect cardiovascular health, cause breast cancer and prostate cancer, and even metabolic disorders. Even breast-feeding mothers are unknowingly contaminating the bodies of their infants with bisphenol A from plastic. However, the microplastic by formation of eco-corona enters living cells, “such as M cells or dendritic cells”, to the lymphatic and/or circulatory system, accumulate in secondary organs, and impact the immune system and cell health.

CONCLUSION

Plastics are well incorporated into the food-web and microplastic get discharged into the environment through a range of sources. These minute plastic particles enter living tissues and cells causing a variety of damage. Ecotoxicological effects of microplastic on biota show that microplastics exposure triggers many toxic effects which is a potential ticking time bomb to the living world. Thus, it is imperative for industrialists to pay heed to warnings of this nature given by these studies, and find ways to mitigate such release — perhaps by utilising better strategies to recycle such smaller plastics more efficiently, or perhaps even create better alternatives. Also, more accountability on the part of industrialists and consumers, along with spreading the word and creating and increasing awareness amongst the common man would be a good start — which in itself would help clamping down on this menace more significantly. After all, mankind is a key stakeholder of nature, and if we don’t fight for this cause, no else one will.

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