PROTEINS

The battle for reading the proteome: Part 1

Accurately identifying and quantifying proteins has been a long-standing technical challenge. Startups are tackling it with audacious approaches.

Abhijeet Patra
Sep 1, 2020 · 11 min read
Source: NIH

What is the proteome?

Why do we need to read it?

In a way, it is a more accurate snapshot of the health of our organism.

What can we learn from the proteome?

Proteins act as catalysts in biochemical reactions.

Proteins provide structure.

Proteins transport small molecules.

Proteins are involved in signaling.

Proteins fight invaders.

Proteins are involved in a variety of functions within an organism. (Photo: Lachlan Mcdonald, Unsplash)

1. Is something wrong?

2. How do we fix what is wrong?

Why is it difficult to identify proteins and measure their abundance?

Progress in lowering costs of genome sequencing. (Source: genome.gov/sequencingcosts)
Left: Concentration range of plasma proteins with the gene names of several illustrative blood proteins (red dots). Concentrations are in serum or plasma and measured with diverse methods as retrieved from the plasma proteome database in May 2017 (http://www.plasmaproteomedatabase.org/) (Nanjappa et al, 2014). Right: Bioinformatic keyword annotation of the plasma proteome database. The blue boxplots with the 10–90% whiskers visualize the range of diverse proteins contributing to distinct functions. From https://www.embopress.org/doi/full/10.15252/msb.20156297

What is the state-of-art?

Discovery

Clinical translation

What do we need?

New kids on the block

Startups are pioneering non-intuitive and disruptive approaches to solve problems that plague proteomics (Image source: Pixabay)

Bioeconomy.XYZ

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Abhijeet Patra

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Investor-Entrepreneur-Scientist. I am interested in and deeply think about interdisciplinary technologies that seem like science fiction, but is just science.

Bioeconomy.XYZ

The Medium publication for biotechnology and everyone involved in the revolution. The best brought to you by the brightest.

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