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Metformin Shows Promise in Slowing Aging in Monkeys
Now in Monkeys
Metformin, a well-established anti-diabetes drug, has been investigated as a potential neuroprotective agent since a study suggested that diabetes patients on metformin outlived age-matched healthy controls2. While subsequent research raised questions about these claims3, metformin remains a strong candidate for further analysis.
A Interventions Testing Program (ITP) study did not find a life-extension benefit in mice treated with metformin4, although smaller studies have produced more favorable results. In various animal models, metformin has alleviated several hallmarks of aging and is associated with reduced health risks in humans. The Targeting Aging with Metformin (TAME) study is expected to clarify the drug’s effects, pending further progress.
A new study conducted by a team of Chinese scientists has broken new ground by examining metformin’s effects in cynomolgus monkeys — a closer biological match to humans than mice.
Improved Cognitive Function
The study lasted 40 months and included a comprehensive evaluation of physiological, imaging, histological, and molecular aspects. The researchers used male cynomolgus monkeys aged 13 to 16 years (equivalent to 40 to 50 human years) for the study group. Three…