Remember to eat at the right time
Mice who feed at unusual times perform less well in tests of learning and memory.
Many processes within the body follow an approximately 24-hour cycle. In addition to patterns of sleep and wakefulness, such circadian rhythms help to regulate body temperature, blood pressure and hormone levels. They also affect when we feel hungry, when our muscles work most efficiently, and when we are mentally at our sharpest.
A region of the brain called the suprachiasmatic nucleus (SCN) generates and maintains circadian rhythms, and thus acts as the body’s master clock. Daily exposure to light keeps the SCN synchronized with the 24-hour day/night cycle. However, most organs, from the heart to the pancreas, also possess their own clocks, which help to regulate organ-specific processes. These secondary clocks normally operate in synchrony with the SCN.
Exposure to light has long been known to influence circadian rhythms. However, more recent evidence suggests that the timing of meals may also affect circadian clocks, particularly those within the digestive system. Dawn Loh and colleagues therefore decided to investigate whether eating outside normal waking hours would also affect other key physiological processes, specifically the cognitive processes of learning and memory.
Mice normally consume most of their food after sunset. Loh and colleagues showed that rodents that were instead fed during the day performed less well on cognitive tests than other mice who received the same food at night. The daytime-fed mice showed changes in a region of the brain called the hippocampus, which supports learning and memory. In particular, daytime feeding changed the timing of the secondary circadian clock within the hippocampus, although it had no effect on the master clock in the SCN. Loh and colleagues therefore suggest that the misalignment of these circadian clocks impairs cognition.
Further experiments are needed to determine whether a similar relationship exists between the timing of meals and cognitive performance in humans. If so, these findings will have implications for the many individuals whose mealtimes, for work or social reasons, are out of synchrony with their body clocks.
To find out more
Listen to Dawn Loh talk about the perils of moving meal times in episode 27 of the eLife podcast.
Read the eLife research paper on which this eLife digest is based: “Misaligned feeding impairs memories” (December 10, 2015).