Gene Expression Is the Key to Age Reversal

Ways To Improve Your Gene Expression

John Iovine
Dec 22, 2020 · 5 min read
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The human genome is key to age reversal. Aging may seem an unstoppable life factor, but the repairing, addition, and expression of genes can positively impact your health and longevity. Aging deteriorates genes and gene expression that maintain youthful functions.

As we humans age, beneficial genes are “turned down”, while other genes that are detrimental to cellular function are “turned up”.

Turned Down

  1. DNA Repair
  2. Inhibition of aberrant cellular reproduction
  3. Glucose uptake via insulin into cells
  4. Production of HDL cholesterol

Turned Up

  1. Interference with cell death of cancer cells
  2. Production of LDL cholesterol
  3. Increase the production of insulin and inflammation
  4. overriding normal cell division

George Church is a geneticist at Harvard Medical School. His specialty, “Age Reversal Gene Therapy.” His work shows that genes be can be restored to reverse aging and to improve overall health. He has achieved these promising results on mice and dogs. We are waiting for human trials, the next step in his research.

Church’s approach is to modify gene and their expression at the cellular level. By turning on youth-promoting genes in cells, we can invoke youthful cellular activity and response. Age reversal may seem impossible, but it has already worked on animals with improvements in rapid action time, healing of damaged tissues, enhanced heart functions, and balanced blood sugar levels.

Age reversal is different from increased lifespan and healthspan because aging is at the genetic level. It does not focus on the strength level and ability to move, although these may improve. Age reversal restores youthfulness at the cellular level and increases the body’s ability to heal damage.

George Church uses his own genome for research in his labs. His lab workers joke that there will soon be more of Church’s genetic material existing in his labs than in his body. Interesting approach. George Church is in his late sixties, so I would imagine any breakthroughs in age-reversal research would be targeted and most effective on his own genome. That in my opinion is incentivized research.

Addition of Genes to your Genetic Code. Create copies of your existing genetic code, say a copy of the code to control blood sugar response. Once you have a sequence, copy it a few times and inject it into your existing genetic code. The additional copies boost the gene function, and voila, your blood sugar is under control. This method is essentially the addition of genes, not the editing of genes.

Gene Expression: Another therapy is boosting the expression of your low performing genetic code. These genes will have the cells producing hormones and enzymes “as if” it was a younger cell. These hormones and enzymes traveling though out your body will trigger other cells to boost youthful functions.

Genetic Repair: Good genes gone bad. CRISPR is entirely different from gene therapy. CRISPR is for editing genes along with their performance. For example, the gene APOE4 increases the person’s chance of getting Alzheimer’s disease. However, if we can get into the brain cells and replace APOE4 with the lower-risk version, APOE2, we can decrease the likelihood of getting this disease.

Gene therapy for reversal aging is not overly complicated on a genetic level. Why? Because you only need to modify two or three of the leading causes of aging to affect a reversal. It is targeting general age-related issues such as osteoarthritis, high-fat obesity, and neurodegenerative diseases. Therefore it isn’t necessary to target and make youthful every cell in the body.

Before we have a general age reversal treatment, we will probably be able to target specific diseases. Replacing a single gene sequence that promotes a particular disease treatment is challenging. These steps will improve the treatment and outcome of patients with diabetes, cancer, heart, kidney diseases, and lowered hormones in the body.

Reversal aging aims to mainly target the older people with declined health conditions as it has shown successful results on old-aged dogs, but for testing it on humans, it still needs some time and FDA approvals before we can test the primary target of the research.

We have some control over gene expression. Ideally, we want to enhance our good genes’ expression while inhibiting the expression of our bad genes.

How do we know what we can do will affect the expression or inhibition of our genes? The answer lies with examining identical genetic twins. Twins with the same genetic code should age in the same manner and develop the same age-related illness and diseases. But they do not. They develop different diseases and illnesses depending upon their lifestyle and environment.

Great, now that we know we can, how do we do that? It’s simple in theory and practice, but that doesn’t make it easy. It boils down to you and your environment. Let’s start with the simplest, a nutritional supplement.

Resveratrol (RSV), a polyphenol found in grapes and other plants like blueberries. Studies have shown RSV bestows benefits that mimic calorie restriction.

Resveratrol is shown in studies to inhibit gene expression for cancer. (source)

Mice fed a high-fat diet have a corresponding increase in weight, triglycerides (TGs), and cholesterol. The addition of RSV in the diet modulated COQ genes to bring TGs to normal levels. (source)

RSV is a multimodal nutrient that positively modulates factors involved in heart disease, cancer, neurodegenerative, inflammation, obesity, and diabetes. (source)

Preliminary studies concluded that 20 mg per day was beneficial. This dosage was derived from the amount of RSV to be found in one liter of red French wine. People who drank approximately a liter per day of red wine derived the cardioprotective benefit that was known as the French paradox.

While human studies were performed used RSV in hundreds or thousands of milligrams per day. I do not recommend anyone take such high doses. You can derive similar cardioprotective benefits with 20 mg of RSV daily. Most capsules are standardized at 100–250 mg of RSV, which should offer greater benefits.

1) Eat healthy and organic (as much as is reasonable).

2) Sleep, you need it. Don’t deprive yourself

3) Meditate. Stress is a killer, and you don’t want Cortisol expressing your genes

4) Exercise told you it was simple, not easy

5) Supplements, resveratrol slows down DNA damage

In as much as is reasonably possible, keep your environment clean. For indoor air pollution, you may want to use HEPA air cleaners with UV sterilization, natural cleaning products, use glass instead of plastic food storage, and drinking cups as possible.

Modifying your environment is not something to obsess or stressed about; that would do more harm than good. My advice is to be mindful of your environment and act accordingly.


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