Shortage of phytonadione for injection
Humans normally obtain their phytonadione from the green leafy vegetables they are urged to eat, and then their bodies change it to the form they can store. First discovered in Germany in the 1920s, it was originally named the Koagulationvitamin, long since known as vitamin K. When blood coagulation goes wrong, the injectable form of phytonadione might be needed, but the American Society of Health-System Pharmacists reports it is in short supply. Overall, humans readily obtain enough phytonadione in their diet. Newborns are usually low in vitamin K at first, and breast milk often doesn’t contain very much. One of the recommendations in the ASHP drug shortage bulletin is to reserve the preservative-free drug formulation produced by Amphastar for use in neonates.
When warfarin is purposefully given to humans to prevent blood clots, vitamin K is used to quickly reverse its effect when necessary for surgery or in any other instance when bleeding needs to be controlled. The antidote for a child who eats rat poison containing warfarin is vitamin K.