Why Some People might be Cannabinoid Deficient?

Migraine, fibromyalgia, and IBS have something in common.

Clinical Endocannabinoid Deficiency. A new disease? Not really. This deficiency has nothing to do with Cannabis use (medical or recreational). It is a deficiency just a shortage of Vitamin D during winter.

Over ten years ago, a medical advisor, examined the evidence from the National Medical Library and came up with a theory. At least three conditions (migraine, fibromyalgia and irritable bowel syndrome — IBS) can have a common underlying cause - Clinical Endocannabinoid Deficiency.

Each system within the human body can develop a pathological disbalance which is called a disease. So can the Endocannabinoid System (ECS). The endocannabinoid system has by far more density of receptors within the human body than many systems; however, no disease has been linked YET to ECS deficiency.

Depression arises when serotonin is low. Alzheimer's disease is due to loss of acetylcholine activity, Parkinsonism due to dopamine deficiency.

Like any other disease, ECS deficiency can be something you are born with or a disbalance that developed later in life. Some conditions are relentless and challenging to manage, but others seem to fluctuate with time or resolve without intervention. We know that anandamide (AEA) is made-on-demand in our body. The level of endocannabinoid can be measured in blood and is known to fluctuate.


Migraine is a genetic disorder (all women from my mother's side have suffered migraines). Some people describe that migraines usually start at a certain age and resolve after many years, often decades. There is a connection to the estrogen level. It is a chronic and remitting condition.

In 1845 Dublin Journal of Medical Science reported in the article “Derangement of the Mind in Connexion with Religion” that four patients with migraine found significant relief after using the extract of Indian Hemp. “Distinct termination of migraine. All patients experienced improvement; some were cured”, described the author of the article.

Later in 1886, A Handbook of Therapeutics published in London reported that Indian Hemp is “found to be the most effective drug for migraine”. Marinol is a synthetic THC, a man-made Cannabis. FDA initially approved Marinol in 1985; now, it is used for AIDS-related anorexia, and chemotherapy caused nausea. Some people use synthetic THC (Marinol) for the prevention and relief of migraine attacks and results are often positive.


Fibromyalgia a known condition with unknown causes; a disease with no clear chemical or anatomical pathology detected. Muscle pain and fatigue are the main symptoms and no precise understanding of how to treat the patients. A recent study tested clinical-grade Cannabis for patients with fibromyalgia. Two compounds were tested: one contained CBD /THC ( Bediol) and another CBD based (Bedrolite). The combination containing both ingredients seems to provide better relief and suggests synergy between CBD and THC.

Irritable Bowel Syndrome (IBS)

IBS is a diagnostic wastebasket as many clinicians call it. It appears to be defined by visceral hypersensitivity, an altered perception of an otherwise normal stimulus like digestion. Management of IBS is difficult; dietary restrictions are tough to follow. Once again, Cannabis helps the symptoms of IBS. The brain and the gut speak the same language.

Endocannabinoids may be the therapeutic neuromodulatory target for all three conditions: migraine, IBS, and fibromyalgia. Cannabis treatment may represent a more effective and safer approach than any other therapeutics. THC’s anti-inflammatory property 20 times that of aspirin and twice that of hydrocortisone. Four Cannabis-derived drugs have been already approved by the FDA.

Up to 2019, available science is not capable of providing all biochemical explanations for cerebral processes and the puzzling functional diseases.

And certain people may just be cannabinoid deficient.

learner, writer, biotech investor, research translation, drug development, genetics. 4-lingual.

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