Health and Disease
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Health and Disease

Photograph by Mark Strozier (CC BY-NC-ND 2.0)

Taking mental health research to a new dimension

Considering psychological traits as existing on a spectrum could advance research into the causes of mental health conditions and perhaps ultimately diagnosis and treatment.

When an individual resists the temptation to stay out late in order to get a good night’s sleep, he or she is exercising what is known as “goal-directed control”. This kind of control allows individuals to regulate their behaviour in a deliberate manner. It is thought that a reduction in goal-directed control may be linked to compulsiveness or compulsivity, a psychological trait that involves excessive repetition of thoughts or actions. Furthermore, evidence shows that goal-directed control is reduced in people with compulsive disorders, such as obsessive-compulsive disorder (or OCD) and drug addiction. However, failures of goal-directed control have also been reported in other mental health conditions that are not linked to compulsivity, such as social anxiety disorder.

The fact that reduced goal-directed control is found across various mental health conditions highlights a core issue in modern psychiatric research and treatment. Mental health conditions are typically defined and diagnosed by their clinical symptoms, not by their underlying psychological traits or biological abnormalities. This makes it difficult to determine the cause of a specific disorder, as its symptoms are often rooted in the same psychological and biological traits seen in other mental health conditions.

To start to tackle this issue, Claire Gillan and colleagues used a strategy that allowed them to look at compulsivity as a “trans-diagnostic dimension”; that is, as something that exists on a spectrum and is not specific to one disorder but involved in numerous different mental health conditions. Nearly 2,000 people completed an online task that assessed goal-directed control, and filled in questionnaires that measured symptoms of various mental health conditions. Gillan and colleagues showed that, as expected, people with reduced goal-directed control were generally more compulsive, and that this relationship could be seen in the context of both OCD and other compulsive disorders such as addiction.

Further, by leveraging the efficiency of online data collection to collect such a large sample, Gillan and colleagues were also able to examine how much different symptoms co-occurred in people. This enabled them to use a statistical technique to pick out three trans-diagnostic dimensions — compulsive behaviour and intrusive thought, anxious-depression and social withdrawal — and found that only the compulsive factor was associated with reduced goal-directed control. In fact, reduced goal-directed control was found to be more closely related to compulsivity than the symptoms of traditional mental health disorders including OCD. These findings show that research into the causes of mental health conditions and perhaps ultimately diagnosis and treatment — all of which have traditionally approached specific disorders in isolation — would benefit greatly from a trans-diagnostic approach.

To find out more

Read the eLife research paper on which this eLife digest is based: “Characterizing a psychiatric symptom dimension related to deficits in goal-directed control” (March 1, 2016).

eLife is an open-access journal for outstanding research in the life sciences and biomedicine.
This text was reused under a Creative Commons Attribution 4.0 International License.

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