The New Magic Mushroom: The Science Behind Adaptogenic Mushrooms

Emily Hu
Health Publication
Published in
4 min readJan 24, 2024

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Mushroom images generated by AI.
Image of various mushroom types generated by AI

The term “adaptogen” has become a popular health and wellness buzzword, and for good reason. Adaptogens are a fascinating category of plants and mushrooms that have the extraordinary ability to help the body positively adapt to various stressors, be it physical, emotional, or environmental. These remarkable substances can help calm an overactive stress response or stimulate a sluggish one, bringing the body back to a state of equilibrium.

Within the realm of adaptogens, adaptogenic mushrooms are gaining attention not only for their adaptogenic properties but also for their other health benefits, including anti-cancer and anti-inflammatory effects. As ongoing research continues to support their potential benefits, their popularity continues to grow. If you are a mushroom lover like myself, this is probably music to your ears. Today we will explore some of the more scientifically proven adaptogenic mushrooms, examine their associated benefits, highlight their generally positive safety profile, and discuss why incorporating them into your daily routine can be great for your overall well-being.

Lion’s Mane (Hericium erinaceus):

Lion’s Mane mushrooms, named for their distinct white and shaggy appearance reminiscent of a lion’s mane, stand out for their abundance of bioactive substances that provide numerous beneficial effects to the body, particularly the brain, heart, and gut. Most notable are their anti-tumor and immunity-boosting properties, along with anti-ulcer, neuroprotection, and neuroregeneration benefits. According to scientific studies, Lion’s Mane may significantly enhance cognitive function and potentially facilitate nerve growth factor (NGF) production. These neuroprotective effects are believed to shield the brain from dementia, reduce depression and anxiety, and expedite recovery from nervous system injuries. This mushroom holds promise for individuals seeking to improve brain health and enhance cognitive performance.

Reishi (Ganoderma lucidum):

Reishi mushrooms, celebrated for their immunity-boosting properties, have been studied for their anti-inflammatory and antioxidant effects. Research indicates potential benefits for cancer prevention, overall immune system support, and stress reduction. While the observed calming effects, especially in relation to stress reduction, have primarily been demonstrated in mice, studies suggest potential applications for humans in managing stress, anxiety, and depression.

Cordyceps (Ophiocordyceps sinensis):

Known for its potential in increasing exercise performance and reducing fatigue, Cordyceps is gaining popularity among fitness enthusiasts. Additionally, it has been explored for its anti-inflammatory and anti-tumor properties, making it a versatile adaptogen.

Chaga (Inonotus obliquus):

Chaga mushrooms are rich in antioxidants, that have been shown to have anti-tumor, anti-inflammatory, and immunity-boosting effects. Although further human studies are still needed to understand their exact impact, their potential health benefits extend to supporting overall immune function and reducing oxidative stress.

Shiitake (Lentinula edodes):

Beyond their culinary appeal, Shiitake mushrooms exhibit more than just great flavor — they are packed with compounds known for their immune-boosting and anti-inflammatory properties. Ongoing investigations have provided promising results in mice, suggesting potential the anti-tumor and cardiovascular benefits of these compounds.

TL;DR: The General Benefits of Adaptogenic Mushrooms

As several mushrooms listed above contain similar compounds, they also share many common benefits. Here are the general benefits of adaptogenic mushrooms in a nutshell.

  1. Stress Reduction: Adaptogenic mushrooms are recognized for their ability to help the body adapt to stress. By modulating the stress response, they contribute to a more balanced and resilient system.
  2. Cognitive Health: Lions Mane, in particular, shows promise in supporting cognitive function and may play a role in maintaining a healthy brain as we age.
  3. Immune System Support: Reishi, Cordyceps, Chaga, and Shiitake mushrooms are all associated with immune system support. Regular consumption may contribute to a robust defense against infections and illnesses.
  4. Anti-Inflammatory Effects: All of the listed adaptogenic mushrooms exhibit anti-inflammatory properties, potentially reducing chronic inflammation and supporting overall health.
  5. Potential Anti-Cancer Properties: Preliminary research indicates that all of the listed mushrooms may potentially have anti-cancer properties. While further studies are needed to confirm these findings, the initial evidence is promising.

How to Take Adaptogenic Mushrooms

Incorporating adaptogenic mushrooms into your routine is a versatile and easy process. These mushrooms can be enjoyed in various forms, depending on your personal preference and lifestyle:

  • Whole Mushrooms: Consuming whole mushrooms, whether raw or cooked, provides a spectrum of nutrients, compounds, and dietary fiber. Cooking may enhance the bioavailability of specific components, particularly those associated with anti-tumor and immunity-boosting properties, contributing to their overall effectiveness.
  • Powder Supplements: Powder supplements provide a concentrated dose of specific mushroom extracts, potentially isolating and increasing the concentration of certain bioactive components. Ensuring maximum potency requires choosing high-quality supplements due to the potential impact of the extraction process on the presence of specific compounds. However, the overall bioavailability of these components in supplements depends on the formulation and the presence of other compounds, which may either enhance or inhibit absorption.

Safety Profile of Adaptogenic Mushrooms

Adaptogenic mushrooms, when sourced from reputable suppliers, are generally safe for consumption. Nevertheless, although unlikely, be cautious about potential allergic reactions and begin with small amounts when experimenting with a new variety.

In conclusion, while many of the benefits associated with certain compounds in these mushrooms have predominantly been demonstrated in animal studies, it’s worth noting that other compounds, such as beta-glucans, have undergone successful human studies, showcasing their potential to enhance human health. The diverse array of bioactive compounds found in these fungi holds substantial promise for improving human health. With documented benefits such as immunity-boosting and anti-inflammatory properties, including a few mushrooms in your daily meals seems like a smart and easy choice. Moreover, considering the absence of substantial downsides and the versatile culinary applications of these mushrooms, there appears to be little risk associated with enjoying a few servings of mushrooms daily. The potential upside in health, coupled with the palatable nature of these fungi, makes them an appealing and low-risk addition to a well-rounded diet.

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Emily Hu
Health Publication

FDA Clinical Trials Expert | Biomedical Engineer | 4x All Time Powerlifting World Record Holder | Author | Angel Investor