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How a DNA Test Revealed the Science Behind My Cannabis Experience
Genetic variations play a pivotal role in how we react to cannabis.
My journey with DNA testing began over a decade ago, following my sister’s breast cancer diagnosis. Given my family’s history — my mother’s breast cancer survival and my aunt’s battle with multiple forms of cancer — I was understandably anxious.
So, I encouraged my doctor to do a BRCA test to determine my predisposition to breast cancer. Back then, genetic testing was a cutting-edge, expensive endeavor, requiring numerous steps for justification to my insurance company for the $3,000 analysis.
Today, genetic tests are more accessible, averaging around $200, and readily available online. Numerous companies offer DNA analysis for a range of purposes, from ancestry information to specialized diets and fitness programs.
These types of tests have always intrigued me, and when I had the chance to explore DNA analysis in an area I’m deeply familiar with—cannabis and endocannabinoid function — I jumped at the opportunity.
I’ve had three DNA tests done now. The one specifically to look for the BRCA gene, one to find my biological father’s family (a story for another time), and one that evaluated my genetic structure for cannabis compatibility.
The Unique Cannabis Experience
Several years ago, my husband and I replaced thirteen pharmaceutical prescriptions using cannabis. During the process, we meticulously documented every product we tried and its effects, soon noticing that despite identical doses, our reactions varied significantly.
Certain strains triggered racing thoughts, paranoia, and anxiety for me, whereas strains high in limonene with a strong citrus aroma could provide relief from the same symptoms. My husband found that edibles alleviated his pain more effectively than smoking or vaping, and we both realized the stark differences in our experiences.
As a former budtender, I observed similar variations among clients — some swore by topicals, while others avoided edibles like the bubonic plague after negative experiences.
