How Muscles Directly ‘Burn’ Fat

High-load resistance training should be considered as an optimal strategy for fat/weight loss.

BioCurious Explorations
ILLUMINATION

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We all know that a sedentary lifestyle increases the risks of various diseases that represent urgent public health concerns such as type 2 diabetes, heart failure, or breast and colon cancer. In the last decades, there is a consensus about the health benefits provided by regular physical activity, however, evidence regarding the molecular mechanisms that transduce these beneficial effects are lacking. Until now.

A new study published in the Federation of American Societies for Experimental Biology (FASEB) journal, showed that high load resistance training causes the overloaded muscles to release so-called micro RNAs that alter specific cellular pathways in fat cells to stimulate increased fat metabolism. Before diving deeper into the molecular biology of these findings, I have to acknowledge the core truth of metabolic science:

Calories ingested versus calories burned is the fundamental and most important formula for fat loss and weight management in general.

However, the percentage of that weight loss that comes from different cell types and tissues (fat vs. muscle, etc.) varies depending on several factors.

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BioCurious Explorations
ILLUMINATION

Unraveling the science behind everyday phenomena. Discover how biomedical insights make sense of the world around you.