Wherefore art thou, dopamine?

It has been three weeks today since the last dregs of Cymbalta left my system. I tapered down for several weeks before that, stopping cold turkey for a couple days due to a mix-up at the pharmacy (0/10, would not recommend).

The short half-life of Cymbalta (duloxetine) means — at least in my experience — that missing even a single dose can cause mild but noticeable symptoms by the next afternoon.

WebMD lists this particular drug as as among the most likely to cause “discontinuation symptoms”, writing that “Symptoms are more likely with antidepressants…