Biology of Dexamethasone: The First Lifesaving Drug for Covid-19

How does it work; how does it fare against other drugs and diseases; its side effects, immunosuppression concerns, and clinical benefits.

Shin Jie Yong
Jun 17 · 6 min read
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Source: melvil / CC BY-SA (https://creativecommons.org/licenses/by-sa/4.0)

The First Lifesaving Drug

The NNT value of dexamethasone in rescuing Covid-19 ventilator-related death is 8, which is impressive by clinical standards.

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How Does Dexamethasone Fare Against Other Drugs?

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How Does Dexamethasone Work?

Dexamethasone stops two phases of inflammation and exerts both anti-inflammatory and immunosuppressive effects.

Dexamethasone’s biological pathways overlap with that of Covid-19 pathology.

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Potential Side Effects

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Immunosuppression Concerns vs Clinical Benefits

In severe pneumonia or ARDS, benefits of glucocorticoids outweigh their immunosuppression concerns, which are seen only in high doses.

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Microbial Instincts

Decoding the microbial angle to health and the microbial world.

Shin Jie Yong

Written by

Freelance writer | Published academic author | 20 y/o neurobiology postgrad in Malaysia | 70+ curated articles on Covid | shinjieyong@gmail.com

Microbial Instincts

Decoding the microbial angle to health and the microbial world.

Shin Jie Yong

Written by

Freelance writer | Published academic author | 20 y/o neurobiology postgrad in Malaysia | 70+ curated articles on Covid | shinjieyong@gmail.com

Microbial Instincts

Decoding the microbial angle to health and the microbial world.

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