Most Long-Covid Biomarkers Are Not That Useful, But One Truly Stands Out

My observations as an academic who has published in this area.

Shin Jie Yong, MSc (Res)
Microbial Instincts

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Image adapted from DALL-E.

Each time a major study announces the discovery of new biomarkers for long-Covid, the news rapidly ignites across media platforms, sparking widespread excitement that we may finally be able to test whether someone truly has long-Covid or not.

But are things that simple? Will science finally reach a point where a simple blood test can determine a long-Covid diagnosis? I find these questions tricky to answer, which is why I’m writing about them.

Recently, several important long-Covid biomarker studies have been published in top academic journals like Nature, Science, and Cell. Even I’ve also published in this area, specifically a meta-analysis of over 20 potential biomarkers of long-Covid. I’ll delve into these studies with a critical eye to understand what they mean in the real, clinical context.

Author’s note: Feel free to skip to the last section for the main takeaways.

Biomarker 1: Complement proteins

The latest long-Covid biomarker study, titled “Persistent complement dysregulation with signs of thromboinflammation in active Long Covid,” was published in Science earlier…

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Shin Jie Yong, MSc (Res)
Microbial Instincts

Independent science writer and researcher | Named Standford's world top 1% scientists | Medium's boost nominator | Elite Powerlifter | Ghostwriter | Malaysian