Overlooked Receptors in Covid-19: What ACE2 Alone Cannot Explain

A multifaceted disease should involve multiple receptors.

Source: Pikist

The fact that ACE2 is not the only receptor for SARS-CoV-2 should not come as a surprise. Covid-19 causes multifaceted symptoms encompassing diverse organ damage. How could only one receptor be responsible for everything? It only makes sense that multiple receptors are involved.

Contents:
1. CD147 Amplifying Covid-19 Virulence
 - The danger of high blood glucose levels in Covid-19.
 - The vulnerability of T-cells to Covid-19.
2. Sialic Acid Amplifying Covid-19 Infection
 - The ability of Covid-19 to target multiple organs.
 - The remarkably high infectivity of Covid-19.
3. Red Blood Cells Amplifying Covid-19 Pathology
 - Antibody clumping that ultimately leads to a blood clot.
 - Lowering haemoglobin counts that carry oxygen.
4. To Sum Up

CD147 Amplifying Covid-19 Virulence

A novel receptor enabling SARS-CoV-2 entry is CD147, also called Basigin (BSG) or extracellular matrix metalloproteinase inducer (EMMPRIN). CD147 receptor is also the entry point for the malaria parasite, Plasmodium falciparum, into red blood cells, and SARS-CoV into human cells.