Maintaining vascular health may help prevent non-Alzheimer’s dementia

Neurology Central presents a study carried out in the Netherlands which investigated whether a multicomponent intervention targeting vascular risk factors is capable of preventing new cases of dementia.

The findings were presented at the Alzheimer’s Association International Conference 2016 (22–28th July 2016, ON, Canada).

It is unclear whether targeting the cardiovascular health and lifestyle-related risk factors with cognitive decline could help to prevent dementia. The Prevention of Dementia by Incentive Vascular Care aims to address this, 
 The trial was an open cluster-randomized controlled clinical trial that took place in primary care over a 6 year period. A total of 3526 cognitively healthy individuals aged 70–78 were randomized to receive either usual care (1636 participants) or usual care plus an additional visits every 4 months (1890 participants) that were led by a nurse and focused specifically on vascular care. The primary outcomes were incident cardiovascular disease, mortality and dementia by subtype.
 Results revealed that the nurse-led vascular care intervention did not reduce all-cause dementia in the healthy population, however a significantly reduced number of non-Alzheimer’s cases were observed in the intervention group compared to the control group. Finally, in study participants with untreated hypertension who attended at least two-thirds of the additional appointments, new dementia cases were fewer in the intervention group in comparison to the control group.
 “Though we were not able to show an effect on the primary outcome, our study shows that long-term, nurse-led vascular care in an unselected population of community dwelling older people is safe and may reduce incidence of non-Alzheimer’s dementia,” commented Richard.
 In addition, we saw potentially clinically meaningful effects in lowering incident dementia in people with untreated hypertension who were adherent to the intervention.”


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