How to determine the best predictor of responses?

Exploiting the use of ROC to determine the best predictor for biomedical research

Kuan Rong Chan, Ph.D.
Omics Diary
Published in
2 min readDec 16, 2023

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ROC curves to determine the suitability of using MCEMP1, HLA-DRA or both to predict severe COVID-19. More details can be found in the publication (Chan et al., eBioMedicine, 2023)

How do you know you have chosen the best biomarker or predictor? The easiest way to visualise is to plot a ROC curve, which also provides information on the sensitivity and specificity of a biomarker.

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Kuan Rong Chan, Ph.D.
Omics Diary

Kuan Rong Chan, PhD, Senior Principal Research Scientist in Duke-NUS Medical School. Virologist | Data Scientist | Loves mahjong | Website: kuanrongchan.com