An Action Potential — An Explanation

Cillian Scott
Pharma Notes
Published in
1 min readApr 26, 2017

Action potential is reached at the Axon Hillock of the axon. A change in membrane potential of ~15–20 mV is sufficient to cause the propagation of an Action Potential. The action potential in a particular neuron occurs as follows.

  1. Resting membrane potential = -70 mV
  2. Summation of graded potentials cause a depolarisation of roughly 15–20 mV at the axon hillock.
  3. Na+ ion-channels open, causing the influx of Na+ ions.
  4. As the Na+ ions flow in, the K+ ion-channels open, allowing the influx of K+ ions.
  5. The change in membrane potential from 0 — +40 mV is called the overshoot.
  6. At +40 mV, the Na+ ion-channels close. Lowering the membrane potential
  7. At 0 mV, the K+ ion-channels close.
  8. The dipping of membrane potential below -70 mV is known as undershoot.

All Action Potentials are roughly 2 ms

All Action Potentials have amplitude of -70 — +40 mV

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