An Epigenetic CRISPR Editor That Can Turn Genes On and Off

A new study presents a programmable epigenetic memory writer that acts as an on-off switch for gene expression

Gunnar De Winter
Apr 17 · 4 min read
(Pixabay, madartzgraphics)

Tagging DNA

Within our cells, we can find the complete DNA recipe to cook up a human being. Most of the DNA of the human genome is found in the cell’s nucleus, with some small DNA fragments floating around in the mitochondria.

CRISPR

CRISPR, or clustered regularly interspaced short palindromic repeats, is the name for DNA sequences that were first identified in bacteria in 1987. As the name suggests, these DNA sequences are short, clustered together, the same if you read them from front to back or back to front (palindromic), repeated, and regularly interrupted by other DNA chunks.

The basic idea behind CRISPR gene editing. (Wikimedia commons, Marius Walter)

Epi(c) CRISPR?

CRISPR is often likened to a cut-and-paste gene-editing tool. Steer it toward the gene you want to alter, cut out the part you want to replace, and paste an alternative in its place.

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Gunnar De Winter

Written by

Science x philosophy x technology x writing — word wrangler & concept cuddler.

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Predict

where the future is written

Gunnar De Winter

Written by

Science x philosophy x technology x writing — word wrangler & concept cuddler.

Predict

Predict

where the future is written

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